In a study funded by our division, Sreya Bagchi, Edgar Engleman, et al. found that increased tumor acidity suppresses inflammatory responses of tumor associated macrophages through GPR65 (an acid-sensing receptor) to drive obesity associated cancer growth in preclinical models. https://lnkd.in/egwAQfAh
NCI Division of Cancer Biology
政府管理
Rockville，Maryland 6,315 位关注者
Supporting fundamental cancer research that lays the foundation for advances in cancer prevention, diagnosis & treatment
关于我们
The Division of Cancer Biology (DCB) of the National Cancer Institute (NCI) supports basic research in all areas of cancer biology, from structural insights to mechanisms of metastasis. These fundamental studies provide the building blocks to new cancer prevention and diagnostic strategies, clinical trials, and anti-cancer treatments. NCI Privacy Policy: https://www.cancer.gov/policies/privacy-security
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https://www.cancer.gov/about-nci/organization/dcb
NCI Division of Cancer Biology的外部链接
- 所属行业
- 政府管理
- 规模
- 501-1,000 人
- 总部
- Rockville，Maryland
动态
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On Nov. 19 & 22 from 7:00 - 7:30 pm ET, we will be hosting a Pancreatic Cancer Awareness Month Twitter/X Chat (#PCAMChat24) at @NCICancerBio. Join Edna (Eti) Cukierman, Kathy DelGiorno, Christopher Halbrook, Ashley Kiemen, Anirban Maitra, Kenneth Olive, Tobiloba Oni, Mara Sherman, and Nina Steele to discuss advances and opportunities in #PancreaticCancer research!
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Did you know that our division provides information and guidance about the?National Institutes of Health Data Management and Sharing Policy?for researchers? https://lnkd.in/eFZ3RqUN
DCB Guidance for the NIH DMS Policy
cancer.gov
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Over the past year, research projects funded by our division have led to new discoveries and advances in fundamental #CancerResearch.?? https://lnkd.in/evSJQ6g9 #NCICancerBioProgress?
Research Advances in Cancer Biology
cancer.gov
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Using a reverse translation approach in a study supported by our division, Kang et al. found that disrupting the Asxl1 gene prevents T cell exhaustion and enhances immune checkpoint blockade in preclinical models. “Our discovery of this molecular checkpoint is a critical advancement for the field because it now allows us to further engineer T cells with a durable anti-tumor response,” said @Benjamin Youngblood (co-lead investigator of the study). https://lnkd.in/eMC_icRj
Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy
science.org
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Notice of Funding Opportunity The National Cancer Institute (NCI) intends to establish a Cancer Immunoprevention Network (CIP-Net) Data and Resource Coordinating Center (CIP-Net DRCC). The CIP-Net DRCC will provide overall data and resource coordination, support, and facilitate collaboration across CIP-Net. https://lnkd.in/emeZ42Xr
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Nov. 8 is the deadline to submit a presentation abstract for the 2025 Systems Approaches to Cancer Biology Meeting (that is partially supported by our division)! The meeting will explore advances and opportunities in cancer systems biology. Sessions will include: ? Tumor Heterogeneity & Evolution ? Metabolism Across Scales ? Immunology & Host-Tumor Interactions ? Systems Pharmacology ? Targeting Signal Transduction https://lnkd.in/eFQQmhGR #SACB2025?
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In a study funded by our division, James Ross, Ph.D., Montse Puigdelloses Vallcorba, Gonzalo Gonzalez-Del Pino, Nishant Kumar Soni, Ph.D., Dolores Hambardzumyan, et al. showed that microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations. Additionally, their mechanistic studies revealed that inhibition of CCR1 and CCR5 (chemokine receptors) reduces macrophage infiltration and extends survival in preclinical models of brain tumors. https://lnkd.in/egQA65sp
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations
cell.com
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Spyridon Bakas will discuss advances in the?federated AI development and how immunotherapy prediction models could utilize these approaches ?in a Society for Immunotherapy of Cancer (SITC) (SITC) - National Cancer Institute (NCI) Computational Immuno-oncology Webinar moderated by Riyue Bao
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Congratulations to the Poster Presentation Award Winners of the 2024 Joint Cancer Systems Biology Consortium (CSBC) and Metastasis Research Network (MetNet) Annual Meeting! #NCIsysbio24
Award Winners at the 2024 Joint Cancer Systems Biology Consortium (CSBC) and Metastasis Research Network (MetNet) Annual Meeting
NCI Division of Cancer Biology，发布于领英