Cureus Channels

Cureus Academic Channels The efficient, low-cost publication platform that every #academic department, #medicalschool and #medical society needs. Fast and efficient for both authors and editors, a Cureus channel will turn your organization into a publishing powerhouse. #publishing #academicpublishing #cureus

Exploring Traditional Remedies for Heart Failure ?? Shakuyaku-kanzo-to (SKT), a Japanese Kampo medicine, shows promise as a therapeutic agent for heart failure (HF): ?? Study Highlights Cardiomyocyte Protection: SKT mitigates angiotensin II-induced hypertrophy and cell death. Mechanisms Uncovered: Reduced intracellular calcium ([Ca2+]i) and reactive oxygen species (ROS) via L-type Ca2+ channel (L-Ca2+) inhibition. Enhanced Efficacy: Co-administration with nifedipine emphasizes SKT's role in antagonizing L-Ca2+ pathways. ?? Implications SKT introduces a new dimension to HF management, emphasizing the need for innovative, integrative approaches in cardiac care. Read more: https://hubs.la/Q02YTKF40 #HeartFailure #Cardiomyopathy #JapaneseMedicine #KampoMedicine #ShakuyakuKanzoTo #InnovativeCare #Cardioprotection #CalciumRegulation #ReactiveOxygenSpecies #AngiotensinII #HeartHealth #IntegrativeMedicine #HFResearch #CureusJournal

ECOG Performance Status (PS) ≥ 3 could redefine prognosis evaluation in hemodynamically stable acute pulmonary embolism (PE) patients with advanced malignancies. This study highlights: Short-Term Outcomes - Zero 30-day mortality in ECOG PS ≤ 2 - 18.8% mortality in ECOG PS ≥ 3 Long-Term Findings - ECOG PS ≥ 3 independently predicts worse overall survival (HR = 4.0, p = 0.002). This approach complements traditional tools like sPESI, emphasizing the need for tailored cancer-PE management. Read more: https://hubs.la/Q02YTGNB0 #PulmonaryEmbolism #CancerCare #ECOGPS #OncologyResearch #PrognosticIndicators #PatientOutcomes #CureusJournal #Hematology #MedicalResearch #CardiopulmonaryCare #VenousThromboembolism #CancerPatients #PEManagement #SurvivalAnalysis #InnovativeMedicine

This case explores a 61-year-old male with severe gingival enlargement (GE) and generalized stage 4, grade C periodontitis linked to methamphetamine use during a period of homelessness. It underscores the critical relationship between substance abuse, GE, and periodontal disease, advocating for heightened awareness and interdisciplinary care in complex cases. Read more: https://hubs.la/Q02YTsCp0 #GingivalEnlargement #Periodontitis #DentalCare #SubstanceAbuse #OralHealth #MethamphetamineEffects #Gingivectomy #OralRehabilitation #InterdisciplinaryCare #QualityOfLife #CureusJournal

Herpes simplex virus (HSV), primarily known for mucosal infections, can cause rare but severe pneumonia, especially in immunocompromised patients. HSV pneumonia often stems from the aspiration of salivary secretions into the lungs, making diagnosis challenging. Simply detecting HSV in respiratory specimens does not confirm active infection. This review sheds light on distinguishing true HSV infection from carrier states, emphasizing timely interventions to improve outcomes. Read more: https://hubs.la/Q02YTtq80 #HSV #HerpesSimplexVirus #HSVInfection #HSVpneumonia #ImmunocompromisedCare #PulmonaryInfections #Acyclovir #CriticalCareMedicine #RespiratoryHealth #MedicalEducation #CureusJournal

Transplant recipients face heightened risks of complications, including pneumonia, a frequent yet challenging condition to manage in immunocompromised patients. Early symptoms may be subtle, underscoring the need for prompt diagnosis and low-threshold empiric therapy. Isolated upper airway pathogens may not always cause pneumonia. Viruses like CMV can act as co-pathogens, influencing infection severity and graft function. Tailored therapy considers antimicrobial resistance, drug interactions, and immunosuppression adjustments. A structured approach ensures early recognition and treatment, safeguarding graft function and patient outcomes. Read more: https://hubs.la/Q02YTrqV0 #TransplantCare #Pneumonia #Immunosuppression #CMV #InfectiousDiseases #SolidOrganTransplant #StemCellTransplant #AntimicrobialResistance #Radiology #EarlyDiagnosis

Discover the future of liver health! ?? GLP-1RAs are showing promising results in tackling MASLD, improving liver function, and more. Dive into the latest research and see how these advancements could change lives! Read more:https://hubs.la/Q02YTlYJ0 #MedEd #Cureus #Hepatology

This report details a groundbreaking case of Candida auris infection in a 72-year-old male with diabetes and hypertension, initially misdiagnosed as pulmonary tuberculosis. Key insights: ?? Diagnostic Challenges: C. auris mimics TB, delaying accurate treatment. ?? Complications: Rare presentation of hydropneumothorax and bronchopleural fistula. ?? Treatment Success: Caspofungin switched to posaconazole, leading to full recovery by three months. This case highlights the importance of advanced diagnostic tools, heightened clinical suspicion, and the efficacy of posaconazole against antifungal-resistant C. auris. Read more: https://hubs.la/Q02Ys7b60 #CandidaAuris #FungalInfections #AntifungalResistance #PulmonaryMedicine #CriticalCare #InfectiousDiseases #Posaconazole #MedicalCaseStudy #CureusJournal #GlobalHealth #Hydropneumothorax #AdvancedDiagnostics

This systematic review investigates the pivotal role of the gut microbiome in Parkinson's disease, a condition impacting over 8.5 million globally. Key findings include: ?? Reduced microbial diversity and specific changes (↓ Firmicutes, ↑ Proteobacteria) ? Altered SCFA production and tryptophan metabolism ??? Links to increased intestinal permeability, neuroinflammation, and alpha-synuclein aggregation Microbiome-based interventions like probiotics, prebiotics, and fecal transplants hold promise in slowing disease progression and improving patient outcomes. However, large-scale, standardized research is needed to unlock personalized treatments. Read more: https://hubs.la/Q02YrZQ40 #ParkinsonsDisease #GutBrainAxis #Neurodegeneration #MicrobiomeHealth #Probiotics #SCFAs #Neuroinflammation #PDResearch #PersonalizedMedicine #CureusJournal #MedicalInnovation #BrainHealth #Microbiota

An 84-year-old woman with simultaneous bilateral proximal humerus fractures (PHFs)—a metadiaphyseal fracture with severe osteoarthritis (OA) on the right and a PHF on the left—was successfully treated with bilateral reverse shoulder arthroplasty (RSA). This case underscores the potential of innovative RSA techniques in managing complex bilateral shoulder injuries and severe OA. Read more: https://hubs.la/Q02Ys4Wl0 #OrthopedicSurgery #ReverseShoulderArthroplasty #ProximalHumerusFracture #MetadiaphysealFracture #Osteoarthritis #ShoulderInjuries #RareCases #Orthopedics #SurgicalInnovation #PatientCare #CaseReport #CureusJournal #ShoulderReconstruction