ASCPT Journal Family

Check out our latest #TranslationalBytes blog on Common language for cancer detection technology! #ASCPTJournalfamily #CTS #cancer #earlydetection https://bit.ly/3RcNMEe.

mRNA-LNP therapeutics hold immense promise, but clinical development challenges remain. This review explores how Model-Informed Drug Development (MIDD) can optimize safety and efficacy evaluation using QSP, PBPK, PK/PD, and more. Read now: https://bit.ly/4iUIGrU #CPTjournal #ASCPTjournals #ClinicalPharmacology

My take on the value of clinical pharmacology in optimizing care of infants with in utero opioid exposure, highlighting the article by Tang in Clinical Pharmacology and Therapeutics. Available open access. #jefferson ASCPT Journal Family

Terrific multidisciplinary work out of Jefferson led by Rupsa Boelig, exploring the pharmacodynamics of aspirin in pregnancy. Thomas Jefferson University ASCPT Journal Family

Have you ever wondered how AI agents could empower clinical pharmacologists, Pharmacometricians, and translational scientists? In our recent publication: " Agents for Change: Artificial Intelligent Workflows for Quantitative Clinical Pharmacology and Translational Sciences" – co-authored with Sirj Goswami, PhD, Sebastian Lobentanzer, and Brian Corrigan, we explore how agentic workflows—integrating specialized AI agents working collaboratively—can streamline complex tasks like PK/PD modeling, optimize clinical trial designs, and enhance precision medicine. We share practical examples, such as the InsightRX Apollo-AI system and the BioChatter Reflexion Agent, discuss opportunities for greater efficiency and informed decision-making, and provide strategies to navigate the integration challenges of these innovative technologies. Collaboration, transparency, and robust regulatory frameworks are crucial to harnessing the full potential of AI for faster and smarter drug development. ?? If you are interested in learning more, please check out our open-access paper here: https://lnkd.in/eb9Zh5Nb #AI #Agents #Agenticworkflows #ClinicalPharmacology #Pharmacometrics #TranslationalScience #PrecisionMedicine #Innovation #AIinHealthcare #DrugDevelopment

New ClinPharmPod Episode Alert! ??? In this episode, we are joined by Clinical and Translational Science (CTS) Editor-in-Chief John Wagner, MD, PhD and Associate Editor Elvin Price to discuss CTS's latest special collection on Diversity, Equity, and Inclusion (DEI) in clinical pharmacology and translational science. ?? What’s in this episode? ? The importance of DEI in our field ? Key trends emerging from the special collection ? The future of DEI-focused research in clinical pharmacology ? Opportunities to submit your research to CTS ?? Listen now: https://lnkd.in/dauHpuiW ?? Explore CTS open calls for papers: https://lnkd.in/dZu7GAR We’d love to hear your thoughts - how do you see DEI shaping the future of clinical pharmacology and translational science? ?? Let’s continue the conversation in the comments! #ClinicalPharmacology #TranslationalScience #DiversityInResearch #DEI #PharmaceuticalScience #ClinPharmPod

New study models lamivudine's transfer from maternal plasma to breast milk in women with HIV on ART—predicting infant exposure & highlighting inter-patient variability. A framework for safer maternal-infant pharmacology! Read more: https://bit.ly/4ij5L7x #PSPjournal #ASCPTjournals #ClinicalPharmacology

New study proposes an extended virtual population algorithm to jointly match tumor dynamics & PFS in oncology QSP models—accounting for censoring & enhancing clinical predictions. A step forward for solid-tumor drug development! Read more: https://bit.ly/3QGwIGn #PSPjournal #ASCPTjournals #ClinicalPharmacology

Characterizing CYP enzymes & transporters in the GI tract: Zhang et al. quantify regional differences in protein abundance among healthy Chinese subjects, informing PBBM refinement. To read more: https://bit.ly/3QJ4Gdh #CPTJournal #ASCPT #ClinicalPharmacology

New study reveals that IL-6R inhibitors elevate imatinib's unbound fraction in critically ill COVID-19 patients - despite increased AAG levels - highlighting the need to monitor unbound drug concentrations for highly protein-bound drugs. Read more https://bit.ly/3QJLrAC? #PSPjournal #ASCPTjournals #ClinicalPharmacology