Zebrafish: A key asset in ophthalmology drug discovery

In this newsletter, we present the zebrafish as an essential resource for ophthalmology research. Check out our last blog, to discover how zebrafish are reshaping ophthalmology drug discovery. Despite advancements, early-stage challenges persist in disease modeling and target identification. Zebrafish offer insights into ocular diseases, including complex conditions like cone dystrophies.

Despite being phylogenetically more distant from humans than rodents, zebrafish share 82% genetic homology with human disease-associated genes, making them valuable for ophthalmology research due to their cone-rich retina and structural similarity to the human macula.?

They are particularly useful in studying ocular diseases, such as cone dystrophies, and have been instrumental in providing pre-clinical data for genetic therapies, including antisense oligonucleotide therapy for Usher syndrome.

At ZeClinics we pioneer visually driven behavioral testing to assess vision acuity, color vision, and light perception efficiently. Our prey consumption assay, a standout test, reveals zebrafish's ability to detect and capture prey, crucial for understanding vision impairment in diseases like cone dystrophy.

Zebrafish's promise spans from disease modeling to evaluating potential therapeutics, marking a paradigm shift in ophthalmic research. Join us in embracing the zebrafish revolution in ocular drug discovery!

Read the full article here.

Insights from ARVO 2024: Harnessing Zebrafish for Ophthalmic Advancements

We recently participated in ARVO 2024, where we had the opportunity to connect with leading scientists and companies in the development of treatments for ophthalmic diseases.

We showcased the potential of zebrafish to rapidly access disease models and undergo comprehensive phenotypic screening, including molecular profiling, histology, and visually-driven behavior analysis.

By integrating in vitro insights from human cells with in vivo functional studies in zebrafish, you can de-risk clinical trials by providing thorough efficacy data.

A rapidly expanding field is gene therapy for ophthalmic disorders. Zebrafish present notable advantages in validating gene therapy constructs owing to their resemblance to the human eye.

Unveiling Environmental Breakthroughs: Key Insights from SETAC 2024 in Seville

Our presence at SETAC 2024 in Seville marked a pivotal moment where we collaborated with leading experts and institutions shaping the landscape of environmental science.

During our presentation, we spotlighted the zebrafish as a game-changer in the one health paradigm:

? Enhancing Environmental Safety

? Revolutionizing Human Health Risk Assessment

? Advancing New Approach Methodologies (NAMs) to uphold the principles of Replace, Reduce, Refine (3Rs)

We want to hear from you!

Do you have any questions or want to discuss your project plans?

Our experts are ready to help you!

Contact us here!