Xenogeneic-Free Human Intestinal Organoids for Assessing Intestinal Nutrient Absorption

“More recently, it is thought that lifestyle-related diseases are prevented by the daily intake of healthy foods instead of medicines. Therefore, much attention has been focused on analyzing food ingredients with the aim of discovering new functional foods. For example, various beneficial ingredients contained in vegetables, fruits, and tea leaves are known to have potential for suppressing cancer risk, improving cardiovascular disease, and shutting down the absorption of sugars and lipids [9]. To evaluate the beneficial effects of functional Nutrients 2022, 14, 438. https://doi.org/10.3390/nu14030438 https://www.mdpi.com/journal/nutrients Nutrients 2022, 14, 438 2 of 12 food substances, studies using the colorectal cancer cell line, Caco-2, or animal models have been carried out. However, differences in the expression level of each transporter in tissue-derived cells from various cell types or species leave doubt about the application of the research findings from these models to humans [10,11]. Hence, an alternative method for the in vitro analysis of the effect of foods on diseases is required” Read more

In this study, we see the demonstration of inhibitory effects on nutrient absorption through nutrient transporters using three-dimensional xenogeneic-free human intestinal organoids (XF-HIOs), with characteristics of the human intestine, as we previously reported. BioChain’s three different healthy human adult small intestinal tissues were used as positive controls. Read more

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