The Wobble Hypothesis: Definition, Statement, Significance

There are more than one codon for one?amino acid. This is called degeneracy of genetic code.?To explain the possible cause of degeneracy of codons, in 1966, Francis Crick proposed?“the Wobble hypothesis”.

According to The Wobble Hypothesis, only the first two bases of the codon have a precise pairing with the bases of the anticodon of tRNA, while the pairing between the third bases of codon and anticodon may Wobble (wobble means to sway or move unsteadily).

The phenomenon permits a single tRNA to recognize more than one codon. Therefore, although there are 61 codons for amino acids, the number of tRNA is far less (around 40) which is due to wobbling.

The Wobble Hypothesis is a concept in molecular biology that explains how the genetic code is interpreted during protein synthesis, specifically in the context of codon-anticodon interactions in the ribosome during translation. It was first proposed by Francis Crick in 1966.

In the genetic code, a sequence of three nucleotides in a messenger RNA (mRNA) molecule is known as a codon. Each codon codes for a specific amino acid, the building blocks of proteins. Transfer RNA (tRNA) molecules are responsible for carrying the corresponding amino acids to the ribosome during translation.

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