Why tablet manufacturing area has negative pressure

It is the common observation that primary tablet manufacturing areas like tablet granulation, compression, coating and mixing areas are maintained at negative pressure or at the low pressure as compared to the adjacent areas.

Like wise other powder processing formulations like dry powder suspensions, capsule filling & any other oral solid dosage form manufacturing areas where powder materials are handled are always kept at the negative pressure or at the low pressure as compared to the adjacent areas.

Did you ever think that why we maintain less pressure inside the primary manufacturing area for the tablet manufacturing or other areas which are involved in the processing of powder or granules dosage forms.?

To understand the facts of above mentioned scenario we must have to be familiar with the purpose and principle of air lock system.

Purpose & Principle Of Airlock?

One of the main and basic purposes of air lock systems is to prevent the cross contamination and protection of clean rooms.

We are familiar that a lock system works on the principle of differential pressure and air moves from the area of higher pressure to the lower pressure.

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