What is the Methylation Detox Cycle, and Why You should care about Liver Health.
The Methylation Cycle is a complex system of feedback loops that help your body breakdown toxins.
Isnt it amazing that your body knows how to do this, even though that Diagram looks really complex and confusing !
It is amazing that " a human can even breathe unattended ".
Your body needs methyl groups to deal with all the stuff that you throw into your body, ( tobacco, alcohol, fructose, sucrose, trans fats, omega 6 fats, difficult proteins, lectins, etc, etc,)
Every cell does this stuff to a degree, but the Methylation Cycle occurs mainly in the Liver.
It utilises B Vitamins, essential trace minerals, and is the basis for production of Serotonin and Dopamine ( neurotransmitters essential for Mental Health )
I hope I have now got your interest and attention.
So please let me highlight 3 parts of your Amazing Detox System
1 The Citric acid cycle and the Ammonia clean-up cycle on the left,
show that each cycle cranks the other cycles.
Methyl groups are donated and released.
The Citric acid cycle starts in your Stomach.
TAKEWAY #1 > Methyl groups are essential.
2 The diagram on the right shows that Vit B2, B6, B12 are needed, and the folate pathway uses methylfolate, the methionine cycle uses methyl B12
For all the B Vitamins to work, they need to be methylated.
B Vitamins are water soluble, and flushed out daily.
Someone who is under-methylated and under stress, will struggle to methylate the required B vits and folic acid to do the job processing the chemicals, fats and proteins,
and start to feel sick, or just feel less than ordinary all the time, and struggle through,
and just flush out un-methylated B Vitamins.
That is why Supplements should be activated B Vits, and Methylfolate,
not just Folic acid.
So SECOND TAKEAWAY.
If you are under a lot of Stress, dont buy normal B Vitamins. Your B Vitamins will not work properly. Your body will just have to try to methylate them. If it cant do that, you will feel sick, and just pee out unusable B vits.
It makes it easier on your Liver, if you have Methylated B vits ( P5P, Methyl B12, methyl folate ) as a supplement. The pharmacist usually keeps these supplements behind the counter. and you need to be aware of issues with Metformin ( diabetes ) and Stomach acid meds. You can , of course, have B12 injections to help rebalance your methylation cycle
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Another way is to take a “ Methyl donor “ as a supplement.
One methyl donor is SAMe , S-adenosyl-L-methionine (SAMe),
aka Methionine. a compound found naturally in the body.
SAMe helps produce and regulate hormones and maintain cell membranes.
Additional SAMe should only be taken with lots of methylated B Vits.
If you really want to know about “ the Methionine Cycle “?,
which is the first complex part of the Methylation Cycle.
Spend some time reading through this link.
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Dont be phased by the intricacy.
Just jot down the stand out facts.
TAKEAWAY #3?
Alcohol decreases SAMe “ available for other methylation.
The reason why SAMe supplement helps with depression is because it helps,jog the Methylation pathway toward producing serotonin and dopamine.
Methyl B12 is also necessary to produce GABA ( helps you get to sleep ).
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Every enzyme requires a trace mineral. Magnesium especially. but also Zinc, Selenium and Chromium. Australian soils are very old and depleted in naturally occuring minerals.
That means your beautiful fresh Australian vegetables ( aka complex soil nutrient modifiers ), can be deficient in essential minerals ( and lack the co factors due to " green ripening" ),
So it may be necessary to take a supplement of these ESSENTIAL trace minerals.
One of those cycles in the diagram on the left ( the Ammonia Clean Up )?is the cycle called the Urea pathway.
If one is low on methylation, one will get symptoms of uric acid build up.
Humans don’t have a great enzyme to break down urea.
High levels of blood uric acid have long been associated with Gouty arthritis (Gout), a medical condition characterized by red, tender, hot, and swollen joints caused by recurrent attacks of acute inflammatory arthritis.
A condition that shows that you are Under-Methylated.
Pathologically, an increase of blood uric acid levels, leads to crystal deposits in joints, tendons, and other tissues and uric acid renal stones.
Traditional medicine knows that diets heavy in fructose, or exposure to " heavy metals " can also contribute to high uric acid levels.
Heavy metal exposure ( Lead, Cadmium, Mercury ) closes down the Enzyme systems, because they block the enzyme receptors, for the minerals that are essential for normal cell function.
Confirmed essential:
Calcium, Magnesium, Zinc, Iron, Copper, Potassium, Sodium, Phosphorus, Iodine, Selenium, Manganese, Chromium, Molybdenum, Boron.
Too much Fructose, and too much Alcohol and Tobacco, occupies the Methylation pathway, so your liver cannot deal with the omega 3 and trans fats, and puts your methylation cycle under pressure.
TAKEAWAY #4
Reduce your Carbohydrate intake. All Carbs are turned into Fructose. Fructose is not regulated by Insulin. Diabetes is a Glucose regulation problem.
You might have a genetic mutation, that prevents your Methyaltion cycle working properly to produce serotonin and dopamine.
In certain humans, a deficiency of enzymes resulting from genetic mutations may also cause increased blood uric acid levels, because the methylation cycle is not working properly.
This is called the MTHFR gene mutation.
In about 2014, I went to see, Dr Heather Way, a world respected gene scientist.
She did 120 gene snps.
> I have HOMOzygous gene mutation for the MTHFR gene,
such that at best, my enzyme systems produce only about 40% of normal
serotonin and dopamine.
I told my Doctor, and he laughed ,
as everyone does when you try to talk about
MTHFR gene mutation.
Yet it is real, and relatively common.
A gene mutation that prevents full expression of Tyrosine to Dopamine,
Trypothan to Serotonin. and Less GABA.
TAKEWAY # 4. You might have a gene mutation, that sets you up as
" an Under-Methylator ".
Most people are just basic struggling to survive,
put a food on the table, bring up their children.
The two main problems in health today are INFLAMMATION and TOXINS.
领英推荐
So NUTRITION is everything.
Bacteria and viruses only attack unhealthy hosts,
especially chronically inflamed sites.
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So,
Some basic fundamentals to turn your health around.
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1 stop eating so much cane sugar. ( buy some Xylitol, a natural plant based sweetener, tastes like sucrose, cooks like sucrose, and does not spike Insulin, )
??????????????? next try to limit Fruit to one serve a day/ 200ml of fruit juice.
2 stop eating so much Carbs ( pasta, pizza, bread )
??????????????? nothing wrong with eating a sandwich, or a bowl of pasta,
?????????? Just limit it. IT doesnt have to be a MEGA meal.
All carbs are broken down to fructose eventually.
Your liver uses the chemical and toxin pathway to breakdown fructose.
Give your Liver a break, and it can clean up toxins stored from the past.
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3 give your Liver a break.
?? ???????????? Have at least one alcohol free day and one meat free day a week.
?? ???????????? Have a fast, a Lent, a Ramadan, a Yom Kippur, a Buddhist fast,
?? ???????????? A Dr Mosley 5 / 2 diet.
?? ???????????? Try a day?a week when you the only liquid that passes your lips
is WATER,
?? ???????????? no coffee, no milk, no juice, no iced coffee, choc milk
?? ???????????? no sports drink, no Coke, no Gatorade etc.
?Eat at Sunrise, after some exercise, and after sunset, after some exercise.
?If you don’t want to be vegetarian, try at least one or two totally vegetarian days each week.
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4 ??????????? avoid omega 6 oils and fats
?????????? ???Use Omega 3 oils.
These are the oils/fats that your liver can easily break down.
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Your liver is built to break down animal fat.
Dont give it trans fats ( from fried food heated oils).
Dont give it chemically extracted oil – from canola, safflower, rice bran, vegetable oil, all mainly omega 6 oils.
even “light olive oil” which is chemically extracted from the waste pulp of Extra Virgin, and added with a bit of 3rd?rate olive oil. and has no vitamins or minerals.
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Extra Virgin Olive oil is like juice of the olive and should taste like you could drink it.
It has a shelf life or it goes off. If it takes like “ dead Olive Oil “ it is not good.
TAKEAWAY #5
Give your liver a BREAK once a week, once a month, once a year
a break from all the things that your Liver has to deal with.
( tobacco, alcohol, fructose, sucrose, trans fats, omega 6 fats, difficult proteins, lectins, etc, etc,)
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Your liver knows how to break down GRASS fed butter, fresh olive oil, avocado, coconut, free range animal fat, and deep sea oily fish ( all omega 3).
It struggles with Omega 6 and Transfats.
Macadamia oil ( equal 3/6 /9) can be used for frying due to its high heat capacity
·?????????It contains up to 85%?monounsaturated fats,?
·?????????It has an unrefrigerated?shelf life?of one to two years
·?????????It has a?smoke point?of 210?°C
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5 ?NONE OF THIS WORKS WITHOUT HYDRATION.
??? Increase your hydration of good clean alkaline mineral rich water.
??? Just drink more mineral water!!!
??? Anytime you think you would like a drink of “ Whatever... “
??? just slug down a glass of water first.
One wine > one water, one beer > one water, One coffee > one water. one fruit juice > one water.
We could expand this to
One Pill or Medicine > one water.
Your Cells dont work if they are dehydrated.
?Dying men ask for “ water “.
Anytime, you want to smoke a cigarette, drink some alcohol, eat some chocolate, eat some lollies, get an energy drink, get a iced coffee, take any of your usual
medication, >
TAKE A BIG GLASS of WATER FIRST.
Think about your Liver.
TAKEAWAY # 6
DRINK A LOT MORE WATER. Good mineral water. pH 7.4.
( tap water is pH 7. )
TAKEAWAY # 7
If you are really serious about your biochemistry and physiology,
Think about getting a Gene test from a Gene Scientist,
who can tailor your nutritional needs,
before you try to self -medicate with Supplements.
or take Presciption medications.
The future of Health Care will start with
1 Gene testing
2 Nutrition
3 Breathing
4 Sleep
5 learning how to de-stress, by Prayer or Meditation or Mindfulness.
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