Let’s explore the latest advancements in ethical science that are shaping the future of research and improving animal welfare.
- Early in-human testing: Implement Phase 0 trials, where microdosing in humans provides early safety and pharmacokinetics data.
- Advanced in-vitro models: Adopt cutting-edge methods like organoids and organs-on-a-chip to replicate human biology in lab settings.
- In-silico methods: Utilize AI simulations and computational models to predict drug behavior, bypassing animal testing.?
- Improved study design: Ensure that preclinical study designs are optimized to minimize the number of animals required by incorporating advanced statistical methods like power analysis.
- Improved drug candidate selection by in-human screening. Reduce the number of failed clinical trials.
- Non-invasive imaging: Use longitudinal imaging techniques to study the same animals over time, reducing the need for animal sacrifice.
- Data sharing: Collaborate with other institutions to avoid redundant animal studies and integrate multiple preclinical studies into one.?
- Higher ethical standards: Work with labs that ensure high-quality housing and care for animals, reducing their stress and improving their welfare.
- Pain management: Ensure protocols include pain-reduction measures like anesthesia and less invasive techniques.
- Behavioral enrichment: Choose laboratories that provide social and behavioral enrichment for animals, improving their well-being during studies.
By adopting the 3Rs, drug developers not only advance animal welfare but can also achieve faster timelines, lower costs, and higher success rates in drug development.
Let’s collaborate to create a future where innovation and ethics go hand-in-hand. ??
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Copyright CC BY-NC 4.0 ? 2024 TRACER CRO
CEO & Founder TRACER | MD, PhD, Professor of Surgery
5 个月Time to re- think the use of animals in drug development and have a careful look at the true representative nature of a human disease model and the use of animals as such!