This Weeks Top Discovery News
Top Discovery News
The researchers detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel miRNAs that were identified in 233 plasma samples from 61 healthy controls and 116 patients with COVID-19 using microRNA sequencing services and computational analysis. The findings may help understand the contribution of miRNAs to the pathogenesis of COVID-19 and identify potential biomarkers and molecular targets for diagnosis and treatment of SARS-CoV-2 infection. (read more)
The RNA sequencing services was used to demonstrate the analysis of significantly differently expressed genes. Cell death was suppressed substantially by NAD+ and NMN supplementation. Mechanically, they found that NAD+ or NMN supplementation partially rescued the disturbed gene expression and metabolism caused by SARS-CoV-2 infection. Thus, their in vivo mouse study supports trials for treating COVID-19 patients by targeting the NAD+ pathway. (read more)
领英推荐
Functional analysis enriched in downregulation of the T-cell receptor and the antigen processing and presentation as well as increased apoptotic proteins, which could lead to T-cell cytopenia. Taken together, four lncRNAs were in part of immune response in COVID-19, which was involved in the T-cell cytopenia by downregulating the antigen processing and presentation, the T-cell receptor, and an increased proportion of monocytes, with a distinct change in cytokines and chemokines. (read more)
Highlighted Technologies
Whole Transcriptome Sequencing (WTS), which includes RNA-Seq with rRNA removal and small RNA-Seq, is used to reveal the complete picture of mRNAs, lncRNAs, circRNAs, as well as microRNA (miRNA), in a biological sample under specific conditions.?
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