This Week's Discovery News

Top Discovery News

Analysis of inter-individual variability of antitussive effect of Farfarae Flos and its fecal metabolites based on gut microbiota?

The results obtained in this study confirm the involvement of commensal microbiota in the antitussive effect of FCM. This is a first step to outline the mechanism of action involved in FCM and open perspectives for therapeutic use of this plant. (read more)

Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota?

Berberine decreased the expression of pro-inflammatory factors such as NOD2, NLRP3, TLR4, and MyD88. With berberine treatment, the relative abundance of Bacteroidetes and Firmicutes was increased significantly, suggesting that berberine could change the intestinal microbiota and improve the intestinal carcinogenesis. (read more)

Spermidine Ameliorates Nonalcoholic Steatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids?

It is intriguing that spermidine inhibits both the hepatic lipid accumulation and the associated liver inflammation. While the underlying mechanisms remain to be clarified, the findings suggest that spermidine ameliorates NAFLD through activation of thyroid hormone-responsive protein signaling and the gut microbiota-mediated transformation of bile acids. (read more)

This Week's Highlighted Technologies

16S/18S/ITS gene sequencing methods are commonly used for identification, classification and quantitation of microbes within complex biological mixture such as environmental samples and gut samples. These genes have a high degree of variation even between closely related species.

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