Weekly Research News Digest
This newsletter is designed to share with you research news in various fields where applications of gene sequencing can be found. It will share research findings from Novogene’s customers. By sharing insights from the most prestigious research teams, it is intended to call your attention to the latest applications of sequencing in life sciences and biomedical research and inspire your research.
We would like to express our heartfelt gratitude for your continued interest?in,?and engagement with,?our Biweekly Research News Digest. Over the past six months, your support has been instrumental in making this column a vibrant platform for the dissemination of cutting-edge research findings and insights. Your enthusiasm and feedback have not only motivated us but also underscored the value of timely and relevant scientific updates. In response to your overwhelming support and the ever-evolving landscape of scientific discovery, we are excited to announce a significant enhancement to our publication. Moving forward, we are transitioning from a biweekly to a weekly publication schedule. This change reflects our commitment to providing you with a more frequent and robust stream of information, ensuring that you stay abreast of the latest developments in your field of study.
This week, we are excited to present five articles exploring?the complex realm of human signal transduction pathways. Researchers employing advanced transcriptome sequencing reveal how cells communicate and adapt to stimuli. Their innovative research provides valuable insights that may contribute to significant advancements in medical research and the development of new therapeutic approaches.
Oxylipins and Metabolites Released from Pyroptotic Cells: Effects on Wound Healing
Pyroptosis is a unique cell death process that not only limits infections but also has links to?sterile?inflammatory and autoimmune diseases. This process involves inflammasome activation and caspase-1, leading to cell death and IL-1β release. The role played by IL-1β in promoting tissue inflammation is so dominant that the effects of other factors released from pyroptotic cells tend to be overlooked. In?a study recently published in Nature, researchers from Belgium, the United States, and Russia jointly?explored effects of these “other” factors with a system in which pyroptosis was induced without IL-1β or IL-1α release (denoted Pyro-1). They?demonstrated that Pyro?1?supernatants?upregulated gene signatures associated with?migration, cell growth, and?wound healing. It accelerated wound healing in vitro and enhanced tissue recovery in vivo. It also contained oxylipins and metabolites, substances?facilitating would healing. These discoveries could lead to innovative therapies for tissue repair.
Understanding KRAS-Driven Pancreatic Cancer: Insights into ERK Pathway and Therapeutic Resistance
The mechanisms through which the KRAS oncogene drives cancer growth have not been well explored. To address this gap, researchers from the United States and Finland conducted a comprehensive analysis of KRAS- and extracellular signal-regulated kinase (ERK)-dependent gene transcription in KRAS-mutant cancers and investigated how these molecular pathways contributed to tumor growth and drug resistance. They identified the ERK mitogen-activated protein kinase (MAPK) cascade as the primary pathway that drove KRAS-dependent gene signature. They also highlighted the critical role played by ERK’s deregulation of cell cycle machinery in driving pancreatic ductal adenocarcinoma (PDAC) growth. The study helps us gain a better understanding of mechanism driving KRAS-mutant tumor growth?and resistance to therapies targeting KRAS-ERK MAPK.
ERK-Regulated Phosphoproteome in KRAS-Mutant Pancreatic Cancer: the Molecular Mechanism Driving Tumor Growth
In order to understand how the ERK1 and ERK2 mitogen-activated protein kinases promote tumor growth in KRAS-mutant pancreatic cancer, researchers from the United States and Finland analyzed the ERK-dependent phosphoproteome. They found that ERK1 and ERK2 exhibited almost identical signaling and transforming effects and that the KRAS-regulated phosphoproteome was largely driven by ERK. They identified 4666 phosphosites on 2123 proteins as ERK-dependent and demonstrated that ERK regulated a highly dynamic and intricate phosphoproteome that focuses on cyclin-dependent kinase regulation and RAS homolog guanosine triphosphatase function (RHO GTPase). The study provides a comprehensive understanding of how ERK drives KRAS-dependent pancreatic cancer growth.
领英推荐
Spermine Regulation of JAK Signaling: Implications for Autoimmune Diseases
Prolonged activation of the type I interferon (IFN-I) pathway?results in?autoimmune diseases such as systemic lupus erythematosus (SLE). This?highlights?the critical role of cytokine signaling in maintaining cellular homeostasis. A joint research team from multiple research?institutions in China found that spermine regulated Janus kinase?(JAK)?signaling by binding to JAK1?and disrupting JAK1 interaction with cytokine receptor, thereby inhibiting JAK1 phosphorylation induced by cytokines. This is particularly important?for patients with SLE, as lower spermine levels were?associated with increased IFN-I and lupus gene signatures, and spermine?treatment?reduced?autoimmune symptoms in mice with?SLE?and?psoriasis?and decreased IFN-I signaling in monocytes from SLE patients. The?researchers?also developed?a spermine derivative that can suppress immune responses. The research?identifies spermine as a metabolic checkpoint for cellular homeostasis and highlights the potential of spermine to be used for managing autoimmune diseases.
Role of PRMT5 in DNA Replication Stress-Induced Transcriptional Activation and?Implications for?Cancer Therapy
DNA replication stress (RS) is frequently seen in the process of cancer development, leading to?genomic instability and chromatin alterations. DNA damage activates innate immune signaling. However, the transcriptional regulators involved in this process under RS are poorly understood. A collaborative research team comprising?scientists from?Singapore, the United States, and South Korea identified protein arginine methyltransferase 5 (PRMT5)?as crucial for RS-induced activation of interferon-stimulated genes (ISGs) and reactivation of endogenous retroviruses (ERVs). They discovered proteins that underwent PRMT5-dependent symmetric dimethylarginine (SDMA) modification during RS. One of these proteins, ZNF326, a zinc finger protein, was regulated by PRMT5 and was vital for the ISG response.?These findings underscore PRMT5's role in RS-induced transcriptional activation, with implications for cancer treatment strategies.
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About Novogene
Novogene specializes in the application of advanced molecular biotechnology and high-performance computing in the research fields of life science and human health. Established in March 2011, Novogene strives to become a global leader in providing genetic science services and technology products. Novogene has set up operations and laboratories in the United States, the United Kingdom, Netherlands, Germany, as well as in China, Singapore and Japan.
Novogene has served over 7,300 global customers, covering 90 countries and regions across 6 continents. It has cooperated extensively with many academic institutions and completed several advanced-level, international genomics research projects. By 2023, Novogene has co-published and/or been acknowledged in more than 22,850 articles in Science Citation Index, with an accumulative impact factor of more than 148,250.
Novogene's partners are worldwide and include more than 4,200 scienti?c research institutions and universities, more than 680 hospitals and over 2,400 pharmaceutical and agricultural enterprises. Currently, Novogene has obtained 356 software copyrights and 66 patents.
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