Despite saving lives, COVID-19 vaccines may have a dark side

Summary:

Vaccines have a dark side despite saving lives: Cancer, thyroid dysfunction, autoimmune hemolytic anemia, emergence of new variants and in extremely rare cases death.

The scope of the problem

Vaccinations are a cornerstone of public health, widely recognized for their role in preventing numerous infectious diseases and reducing mortality worldwide. No doubt vaccines save lives. However, like all medical interventions, vaccines can have side effects. While the vast majority are minor and transient, research acknowledges rare cases where vaccines may lead to adverse effects. Comprehensive studies, including those by researchers such as Professor Abdollah Jafarzadeh affirm adverse effects such as thyroid dysfunction, hemolytic anemia and in extremely rare instances, more severe conditions, despite the significant advantages of vaccines in controlling outbreaks and saving lives.

A recent review by Alberto Rubio-Casillas, David Cowley, Mikolaj Raszek, Vladimir N. Uversky, and Elrashdy M. Redwan has raised concerns about the potential impact of mRNA vaccines on cancer development.

The rapid implementation of mRNA vaccines was necessary due to the health emergency created by SARS-CoV-2, the virus that causes COVID-19. These vaccines have attracted significant interest and offered a lot of hope. However, their potential in preventing hospital admissions and serious illness in people with comorbidities has recently been called into question due to rapidly waning immunity.

The review suggests that mRNA vaccines do not generate sterilizing immunity, leaving people vulnerable to recurrent infections. Moreover, it has been discovered that these vaccines inhibit essential immunological pathways, impairing early interferon signaling. This inhibition ensures appropriate spike protein synthesis and reduced immune activation within the framework of COVID-19 vaccination.

The authors provide evidence that adding 100% of N1-methyl-pseudouridine (m1Ψ) to the mRNA vaccine in a melanoma model stimulated cancer growth and metastasis. In contrast, non-modified mRNA vaccines induced opposite results, suggesting that COVID-19 mRNA vaccines could aid cancer development.

Furthermore, ongoing surveillance and research are crucial as vaccines can exert selective pressure on viruses, potentially leading to the emergence of new variants. This phenomenon underscores the importance of continuous monitoring and adaptation of vaccine strategies to maintain efficacy against evolving pathogens. On the other hand, uncontrolled viral spread in unvaccinated populations can be a much more significant driver of mutation. Vaccines, by controlling the spread of viruses, generally reduce the chances of new, more dangerous variants emerging. Given this consideration, again the benefits of vaccination possibly outweigh the risks. Despite the dark side, the overarching message from health authorities and researchers is that the benefits of vaccinations overwhelmingly outweigh the risks.

References:

Jafarzadeh A, Nemati M, Jafarzadeh S, Nozari P, Mortazavi SMJ. Thyroid dysfunction following vaccination with COVID-19 vaccines: a basic review of the preliminary evidence. J Endocrinol Invest. 2022 Oct;45(10):1835-1863. doi: 10.1007/s40618-022-01786-7. Epub 2022 Mar 26. PMID: 35347651; PMCID: PMC8960081. https://pubmed.ncbi.nlm.nih.gov/35347651/

Jafarzadeh A, Jafarzadeh S, Pardehshenas M, Nemati M, Mortazavi SMJ. Development and exacerbation of autoimmune hemolytic anemia following COVID-19 vaccination: A systematic review. Int J Lab Hematol. 2023 Apr;45(2):145-155. doi: 10.1111/ijlh.13978. Epub 2022 Oct 8. PMID: 36208056; PMCID: PMC9874780. https://pubmed.ncbi.nlm.nih.gov/36208056/

Jafarzadeh A, Gosain R, Mortazavi SMJ, Nemati M, Jafarzadeh S, Ghaderi A. SARS-CoV-2 Infection: A Possible Risk Factor for Incidence and Recurrence of Cancers. Int J Hematol Oncol Stem Cell Res. 2022 Apr 1;16(2):117-127. doi: 10.18502/ijhoscr.v16i2.9205. PMID: 36304732; PMCID: PMC9547773. https://pubmed.ncbi.nlm.nih.gov/36304732/

Mortazavi, S. M. J., et al. (2023). "Should We Fear A Wave of Cancers After the COVID-19 Pandemic?" Journal of Biomedical Physics and Engineering. in press. https://jbpe.sums.ac.ir/article_49750.html

Rubio-Casillas, A., et al. (2024). "Review: N1-methyl-pseudouridine (m1Ψ): Friend or foe of cancer?" International Journal of Biological Macromolecules 267: 131427.https://doi.org/10.1016/j.ijbiomac.2024.131427

Mortazavi, S. A. R., et al. (2023). "Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective." Journal of Biomedical Physics and Engineering. in press. https://jbpe.sums.ac.ir/article_49625.html

Mortazavi, Seyed Mohammad Javad, B. F. Bahaaddini Baigy Zarandi, Abdollah Jafarzadeh, S. Alireza Mortazavi, and Lembit Sihver. 2022. "COVID-19 Update: The Golden Time Window for Pharmacological Treatments and Low Dose Radiation Therapy" Radiation 2, no. 3: 268-272. https://doi.org/10.3390/radiation2030020 , https://www.mdpi.com/2673-592X/2/3/20

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