A User's Guide to N-of-1 Trials for Longevity Enthusiasts
Being very passionate about their health, longevity enthusiasts are naturally curious about trending supplements and therapies. However, when they ask longevity scientists about these trends, the usual response is, “There isn't enough evidence.”
Well, what if you could be your own evidence?
When scientists mention a lack of evidence, they typically refer to the lack of large randomized controlled trials on a specific treatment — usually because these trials are expensive and labor-intensive to conduct. However, N-of-1 trials present an alternative; a tailored and reliable alternative.
In these experiments, you're the only subject. You can also be the investigator. And you will act as both the treatment and control arms of the trial.
Let's break it down with an example. Say you're considering an NMN supplement. This is how you can run an N-of-1 trial to generate evidence:
For example, improved cardiorespiratory fitness.
In that case, VO2 max could be an option.
For example, four-week intervals, while measuring VO2 max in both phases.
Compare the results from both phases to see if NMN had a measurable impact.
Of course, this is an oversimplified protocol. However, numerous N-of-1 studies have been published with transformative results for their subjects. Read N-of-1 success stories [HERE].