Unraveling the Mystery of Type 1 Diabetes!
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Cutting-edge research from Hebrew University challenges the traditional view of viral involvement in early-stage type 1 diabetes (T1D). In a paradigm-shifting study, the team introduces a groundbreaking model that links disrupted RNA editing within pancreatic beta cells to an inflammatory response mimicking early-stage T1D.
Key findings:
Defective RNA editing triggers a massive inflammatory attack in beta cells, resembling T1D.
High blood glucose levels intensify the inflammatory response, creating a vicious cycle.
The study proposes a new perspective, highlighting "the enemy within" rather than external viral triggers.
Led by Prof. Yuval Dor, Dr. Agnes Klochendler, and MD/PhD students Ehud Knebel and Shani Peleg, the research challenges the long-standing belief in viral initiation of T1D. The team's work on RNA editing provides compelling evidence for a novel view of T1D development, with profound implications for prevention and treatment strategies.
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Prof. Yuval Dor emphasizes, "Our research presents compelling evidence that disruption of RNA editing within beta cells can trigger an inflammatory response resembling early-stage type 1 diabetes. This offers a new view for how T1D may develop, with implications for prevention and treatment strategies."
Dr. Agnes Klochendler adds, "Identifying a link between natural double-stranded RNA in beta cells, inflammation, and diabetes opens a new perspective on T1D: a paradigm of 'the enemy within,' not necessitating external viral infection as the triggering event for this disease."
Published by the Hebrew University-Hadassah Medical School, Bar-Ilan University team, this research challenges the status quo and provides a fresh outlook on T1D etiology.
Read the full study for groundbreaking insights: [Knebel, U. E., et al. (2023). Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes. Cell Metabolism. doi.org/10.1016/j.cmet.2023.11.011.]
Let's spread awareness and explore new avenues for treating and preventing Type 1 Diabetes!
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