Under the Microscope with NIS

Under the Microscope with NIS

Quantitative Encapsulation Efficiency Analysis of Lipid Based Formulations

Payload distribution and drug loading fraction influences formulation efficacy and safety.

Quantitative, per-particle analysis of cryo-TEM images provides detailed information about:

  • Liposomal drug encapsulation
  • LNP payload, without the need for labeling
  • Per-particle mRNA, DNA, and nucleic acid distribution analysis

Learn more about our R&D and method validated analysis.

Cryo-TEM images showing mRNA encapsulated LNPs (top left), DNA encapsulated LNPs (top right), and pegylated liposomal doxorubicin vesicles that contain fibrous crystals (bottom).

Registration is now OPEN for the NESBA Cryo-EM Mini Symposium on October 3rd!

Hear from drug discovery experts during a half day cryo-EM symposium, from 1:30-5pm focused on the applications of structural biology to structure-based drug discovery.

Speakers include:

  • Sanofi Structural Biology Team
  • Joe Arndt, Biogen
  • Richard Walsh, Harvard Cryo-EM Center for Structural Biology
  • Kevin Huynh, Pfizer
  • Priyamvada Acharya, Duke Center for HIV Structural Biology at Duke University
  • Kurt Swanson, Ring Therapeutics
  • Christine Carbone, Relay Therapeutics
  • Mira May, Massachusetts Institute of Technology
  • Ximena Barros-álvarez, Tectonic Therapeutic

Registration is limited, sign up now.

?Don't miss out on the networking reception from 5-7pm at the Lexington for drinks, appetizers, and conversation with leading experts!

The event will be hosted by Sanofi at Cambridge Crossing, co-organized & sponsored by NanoImaging Services with additional sponsorships from Refeyn & Clovertex.

We'll be at these conferences & events, will you? Message us to schedule a meeting, or visit us at our booth.


6th Exosome Based Therapeutic Summit

September 18-19 | Boston, MA

Join Dr. Brent Wood, Dr. Sarah Dunn, and Samantha Tipton to learn how cryo-TEM can image and analyze extracellular vesicles and exosomes. Schedule a meeting.


NESBA Cryo-EM Mini Symposium

October 3 | 1:30-5:30 pm

Sanofi Headquarters | Cambridge, MA

Hear from drug discovery experts at Biogen, Pfizer, and more during a half day cryo-EM symposium focused on the application of structural biology to drug discovery.

Only 100 seat are available, so sign up now!


AAPS 2024 PharmSCI 360

October 20-23 | Salt Lake City, UT

Join Dr. Sarah Dunn & Dr. Mandy Janssen to learn how cryo-TEM imaging & automated analysis can help visualize CQAs of any nanoparticle, from R&D through to?method validation.


7th Annual Targeted Protein Degradation

October 29-30 | Boston, MA

Join Dr. Kenny Kang, Dr. Sarah Sulley, and CCO Kristin Rider to learn how cryo-EM can improve structure determination of degraders such as PROTACs and molecular glues.


6th Annual Gene Therapy Analytical Development & CMC Summit

October 31-November 1 | Boston, MA

Join Dr. Eric Bushong, Dr. Sarah Dunn, and Samantha Tipton to discuss how?cryo-TEM imaging?and quantitative analysis can improve?gene therapy?vehicles from R&D through to?method validation.


Eastern Analytical Symposium

November 18-20 | Plainsboro, NJ

Join Dr. Mandy Janssen, Dr. Maryam Ghaisse, Dr. Sarah Dunn, and Samantha Tipton to learn how?cryo-TEM per particle imaging and quantitative analysis can span?from R&D through to?method validation.

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