Uncover the Role of Riboflavin in Methylation Now!

The methylation cycle is a series of chemical reactions that occur in the body, in which methyl groups are added to and removed from molecules such as DNA, RNA, and proteins. Methylation is a process that affects the expression of genes and can play a role in continuing good health.

How Riboflavin Plays a Role in Methylation Biochemistry

Riboflavin is required for the activity of the enzyme flavin adenine dinucleotide (FAD)-dependent methylene tetrahydrofolate dehydrogenase (MTHFD2), which catalyzes the conversion of 5,10-methylene tetrahydrofolate to 5-formyl tetrahydrofolate. This is an important step in the methylation cycle because it generates formyl tetrahydrofolate, which is a precursor for the biosynthesis of purines, pyrimidines, and methionine.