Separations for Complex Samples - an unmet need in pharmaceutical analysis until now
Michael Dong
Subject matter expert in HPLC, CMC, and pharm analysis. PhD in analytical chemistry. Author of bestseller HPLC book and 130 articles.
If you are currently working on a separation problem on a complex drug substance such as an NCE with multiple chiral centers or a drug product with multiple APIs, this white paper may be useful to provide you with an overview of the latest advances and some effective strategies for method development of these complex samples. This paper includes suggestions for ideal column and operating parameters, QC implications and validation data.
M. W. Dong, D. Guillarme, S. Fekete, R. Rangelova, J. Richards, D. Prudhomme, and N. P. Chetwyn. High-resolution separations of complex pharmaceuticals by UHPLC: Case studies and quality control implications, LC GC North Am. 32(11), 868-76, 2014.
Send questions or reprint requests to [email protected]
Posted by Michael Dong on 6/4/16
Subject matter expert in HPLC, CMC, and pharm analysis. PhD in analytical chemistry. Author of bestseller HPLC book and 130 articles.
8 年Uhplc is the newest weapon for the unmet need of complex sample separations