Tripeptide Libraries

Peptide libraries consist of a combination of different peptides for use in a number of biological applications. These combinations can include overlapping peptides, random sequences, truncated sequences, among others. The general synthetic peptide library uses 20 kinds of natural amino acids as building units, and the size of the library capacity is determined by the number of amino acids (n) that constitute a peptide of a specific length, which can be simply calculated as 20n, a tremendous number of peptides can be generated with the peptide sequence lengthening. Based on GenScript’s PepHTS platform, we provided highly efficient peptide library synthesis service, and we have accomplished a tripeptide library contains all the 8000 (20*20*20) sequences of natural amino acid through chemical synthetic method.?

By analyzing hundreds of peptides in parallel, peptide libraries drastically decrease the time required for screenings. Since the natural sourced and tremendous potential sequences, peptide libraries show powerful strength in the application of:

·??????epitope mapping / screening

·??????protein structure-activity study

·??????cancer vaccine

·??????drug discovery

·??????spacer amino acid positions

·??????food and cosmetic development.

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Reported tripeptides:

(1)??ECG(Glu-Cys-Gly)-(glutathione), antioxidant, cofactor;

(2)??EHP(Glu-His-Pro) -stimulates pituitary gland controlling thyroid-stimulating hormone secretion

(3)??FEG(Phe-Glu-Gly) -inhibition of anaphylaxis, anti-inflammatory, modulatesleukocyte adhesion

(4)??GHK(Gly-His-Lys) -tissue remodeling and wound healing

(5)??PLG(Pro-Leu-Gly) -modulator of the dopamine D2 receptor

(6)??DLF/SLF(Asp<Ser>-Leu-Phe) -inhibition of β protein of bacterial replisome, antimicrobial

(7)??ELR(Glu-Leu-Arg) -chemokine, growth factor binding motif

(8)??GGQ(Gly-Cys-Gln) -release factor, stop codon recognition

(9)??GPE(Gly-Pro-Arg), neuroprotection

(10) HAV(His-Ala-Val) -cadherin motif, cell-cell interactions, and adhesion

(11) HGK(His-Gly-Lys) -vitronectin inhibition

(12) HPQ(His-Pro-Gln) -streptavidin binding motif

(13) KPV(Lys-Pro-Val) -anti-inflammatory properties

(14) LDV(Leu-Asp-Val) -vascular cell adhesion molecule 1 (VCAM-1)/fibronectin adhesion motif

(15) RGD(Arg-Gly-Asp) -cell adhesion signal

(16) SKL(Ser-Lys-Leu) -peroxisomal targeting

(17) KYL(Lys-Tyr-Leu) -vasoactive intestinal peptide (VIP) motif

(18) RER(Arg-Glu-Arg) –sAPP motif, neuroprotection

Characteristics of GenScript’s Tripeptide Library:

1 Other salt form can be customized: chloride, acetate, phosphate, etc..

2 Additional QC test available, Contact us for detail.

3 Delivery time may vary depend on your specific requirements

GenScript’s Tripeptide library can be delivered as both single separated product and customized mixture. Also, partial or full sequences is available.

Quality Assurance:

??ISO 9001 certified;

??GenScript Total Quality Management (TQM) platform;

??AccuPep+QC Platform: validated equipment and test method available;

??ArgonShield package: GenScript’s breakthrough technologies are designed to deliver assay ready peptides of the highest quality.

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Peptide Service from GenScript

GenScript provides a full spectrum of high-quality peptide services ranging from Custom Peptide Synthesis (research and cGMP grade with Regular and Express deliveries) to high-throughput Peptide Library service. With access to the state-of-the-art equipment and experienced chemists using the latest technologies, we have delivered over 600,000 custom peptides to more than 10,000 scientists worldwide.

For more details of GenScript’s Tripeptide library products and peptide synthesis services, please contact us with the contact information below:

[email protected]