Top 20 Pharmaceutical Firms / Revenue 2022 & Market Cap 2023

Top 20 Pharmaceutical Firms / Revenue 2022 & Market Cap 2023

For the first time in biopharma history, a firm has topped the $100 billion mark in annual revenue.?Pfizer passed?that milestone, propelled by its massive haul from its COVID-19 products. Its BioNTech-partnered vaccine, Comirnaty, raked in $37.8 billion, and oral antiviral Paxlovid made $18.9 billion.

Subtract the COVID treatments from Pfizer’s top line and its revenue would be $43 billion, which is right in line with the firms pre-pandemic sales. The Big Pharma's sales gradually increased from $40.8 billion in 2018 to $41.6 billion in 2020.

With its windfall, Pfizer displaced Johnson & Johnson as the industry’s No. 1 revenue generator. J&J had occupied that position for a decade and had been closing in on the $100 billion mark. Sales for 2021 and 2022 came in at $93.8 billion and $94.9 billion, respectively.

But with J&J on the verge of separating from its consumer health business, its overall revenue will take a tumble. The unit, dubbed Kenvue, accounted for $15 billion of J&J’s sales last year.?

It might be a while before a company tops the $100 billion mark again. With sales of COVID products expected to decline sharply, Pfizer is projecting its revenue to come in at between $67 billion and $71 billion in 2023.

Pfizer had a gaudy 23% revenue increase over 2021, the second largest jump among the top 20 revenue generators. The top gain was registered by Novo Nordisk, which saw a 26% surge,?owed largely to demand for its diabetes and obesity products Ozempic and Wegovy.

The only other companies in this heady territory were Merck, with a 22% increase, and AstraZeneca, with an 18% boost.

Merck rode the coattails of cancer superstar Keytruda, which rang up $20.9 billion, and COVID oral antiviral Lagevrio, which pulled in $5.7 billion. AZ owes its growth largely to $2.2 billion in sales of short-lived COVID antibody Evusheld plus major sales gains from blockbusters Calquence, Farxiga and Ultomiris.

Right behind Merck, which ranked No. 4 in revenue, was No. 5 AbbVie, which also was propelled by a single megablockbuster. Generating $21.2 billion in sales, Humira accounted for 35.6% of AbbVie’s revenue, compared to Keytruda’s 35.2% share of Merck’s sales.

The lone companies that saw a significant revenue decline were GSK (11%) and BioNTech (9%). GSK's decrease can be chalked up to its separation from consumer health unit Haleon, which reported sales of 10.9 billion pounds sterling ($13.4 billion). Take Haleon out of the equation, and GSK actually had a healthy revenue gain.

BioNTech's revenue drop came from declining sales of its lone commercial product, the Comirnaty vaccine it shares with Pfizer.

Small revenue declines were registered by Novartis (2%), Bristol Myers Squibb (0.5%) and Gilead Sciences (0.1%).

Falling out of the top 20 from last year is Viatris, which saw a 9% revenue decline in 2022, continuing a sales slide that began in 2020. Entering the top 20 is Merck KGaA on the strength of a 13% sales increase.


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HQ: New York City, USA / CEO: Albert Burelo

1.Pfizer

2022 revenue:?$100.33b

2021 revenue:?$81.29b

Market Cap 2023: $226.96b





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HQ: New Brunswick, New Jersey / CEO: Joaquin Duato

2. Johnson & Johnson

2022 revenue:?$94.94b

2021 revenue:?$93.77b

Market Cap 2023: $510.84b





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HQ: Basel, Switzerland / Group CEO: Thomas Schinecker

3. Roche

2022 revenue: $66.26b

2021 revenue:?$62.80b

Market Cap 2023: $253.84b





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HQ: Kenilworth, New Jersey / CEO: Robert Davies



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HQ: North Chicago, Illinois / CEO: Richard Gonzalez

4. Merck

2022 revenue: $59.28 billion

2021 revenue: $48.70 billion

Market Cap 2023 : $289.93b



5. Abbvie

2022 revenue:?$58.05 billion

2021 revenue:?$56.20 billion

Market Cap 2023: $287.45b




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HQ: Basel, Switzerland / CEO: Vasant Narasimhan


6. Novartis

2022 revenue:?$50.54 billion

2021 revenue:?$51.63 billion

Market Cap 2023: $212.59b



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HQ: New York City, USA / CEO: Giovanni Caforio

7. Bristol Myers Squibb

2022 revenue:?$46.16 billion

2021 revenue:?$46.38 billion

Market Cap: $147.53 billion






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HQ: Paris, France / CEO: Paul Hudson

8. Sanofi

2022 revenue:?$45.22 billion

2021 revenue:?$44.63 billion

Market Cap 2023: $142.83b



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HQ: Cambridge, UK / CEO: Pascal Soriot

9. AstraZeneca

2022 revenue:?$44.35 billion

2021 revenue:?$37.42 billion

Market Cap 2023: $234.33b





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HQ: Cambridge, UK / CEO: Emma Walmsley

10. GSK

2022 revenue:?$36.15 billion

2021 revenue:?$46.92 billion

Market Cap 2023: $75.16b




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HQ: Tokyo, Japan / Christopher Weber

11. Takeda

2022 revenue:?$30.00 billion

2021 revenue:?$31.57 billion

Market Cap 2023: $52.88b




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HQ: Indianapolis, USA / CEO: David Ricks

12. Eli Lilly

2022 revenue:?$28.55 billion

2021 revenue:?$28.32 billion

Market Cap 2023: $356.18b





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HQ: Foster City, Calafornia / CEO: Daniel O Day

13. Gilead

2022 revenue:?$27.28 billion

2021 revenue:?$27.30 billion

Market Cap 2023: $105.76b




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HQ: Leverkusen, Germany / CEO: Bill Anderson

14. Bayer

2022 revenue:?$26.64 billion

2021 revenue:?$27.94 billion

Market Cap 2023: $65.46b









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HQ: Thousan Oaks, Calafornia / CEO: Rober Bradway

15. Amgen

2022 revenue:?$26.32 billion

2021 revenue:?$25.98 billion

Market Cap 2023: $130.27b



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HQ: Ingelheim am Rhein, Germany / CEO Jean Michael Boers

16. Boehringer Ingelheim

2022 revenue:?$25.28 billion

2021 revenue:?$24.24 billion

Market Cap: privately owned




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HQ: Bagsvaerd, Denmark / CEO: Lars Fruergaard Jorgensen

17. Novo Nordisk

2022 revenue:?$25.00 billion

2021 revenue:?$22.38 billion

Market Cap 2023: $388.18b







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HQ: Cambridge, Massachusetts / CEO: Stephane Bancel

18. Moderna

2022 revenue:?$19.26 billion

2021 revenue:?$18.47 billion

Market Cap 2023: $54.32b









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HQ: Darmstadt, Germany / CEO: Belen Garijo

19. Merck KGaA

2022 revenue:?$19.16 billion

2021 revenue:?$19.11 billion

Market Cap 2023: $77.08b



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HQ: Mainz, Germany / CEO: Ugur Sahin

20. BioNTech

2022 revenue:?$18.20 billion

2021 revenue:?$22.43 billion

Market Cap: $28.50 billion

Elham A.

Medical Director, North America Medical Affairs, CSL Behring

1 年

Great article …

Karim SHAKER

Country Head Gulf Countries | Executive MBA, OTC Markets Expert

1 年

Informative and to the point…thanks Michael

Ahmed Eldiry

Senior Medical Sales Executive @ Globalpharma LLC | MBA | Business Development | Pharmaceuticals

1 年

Very helpful ??

Yamen Abdel Aziz

Pharma Business Leader | I coach and mentor mid-career professionals on how to make a progressive career in the pharmaceuticals industry, create impact and take charge of their promotions

1 年

Very informative article, thanks for sharing Michael!

Cedric Rebeiro

E2E Supply Chain Strategy & Operations | Pharmaceutical | Active Pharmaceutical Ingredients | Consumer Health & FMCG | SCMC CoE @ IIMB | Management Consulting | India | GCC, Levant, Iran, Iraq | AfMET

1 年

Very informative.

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