TNA-Based Probes for miRNA Detection
Knowledge Transfer Office, City University of Hong Kong
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The development of nucleic acid-based probes for the detection of microRNAs (miRNAs) in living cells is of significance in understanding their biological functions and guiding the disease diagnosis and prognosis, for example, cancer. However, their development into viable diagnosis systems has faced challenges with regard to enzymatic degradation, nuclear sequestration, high false-positive signal, cytotoxicity and the demand for transfection agents. Thus, it is imperative to develop rapid, convenient, cost-effective and sensitive approach for in situ detection of miRNA expression at single cell level. Due to the flexibility offered by natural nucleic acids, hybridization-based probes have recently become hotspots in endogenous miRNA detection research. Therefore, to develop hybridization-based probes for miRNAs detection is with great potential.?
#ThreoseNucleicAcid #TNA #MicroRNA #FluorescenceImaging #DynamicRealTimeMonitoring #NucleicAcidBasedProbes #CancerCell #miRNADetection #DiseaseGenesisMonitoring
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