Tips for high-speed assembly of lateral flow cassettes

Manufacturers constantly struggle with the dilemma of flexibility or high speed when it comes to process automation. Kinematic Automation has nearly 43 years’ experience in dealing with these issues and can offer valuable insight.

It is possible to have a flexible platform and still be able to assemble lateral flow cassettes at speeds exceeding 60ppm. It all comes down to planning, the right cassette design and, of course, the right automation equipment. Kinematic was founded in 1980 and, for nearly 43 years, has specialized in process automation for the medical device industry. The company understands all of the intricacies of test strip manufacturing and has a number of standard platforms to support their client partners around the globe. It also offers custom solutions for unique applications.

Plan ahead

A good outcome generally comes from a good plan. For flexible, high-speed automation to be most successful, it is ideal to have as much commonality between components as possible. While individual test-strip laminations, dimensions and materials can differ significantly, commonality between cassettes is beneficial.

Cassette design is key

Ideally, plastic cassette components should be fed from feeder bowls for maximum efficiency. Thus, for different products, cassettes should all be externally identical, with the only differences being internal features necessary for accommodating different test strip width, length or thickness. Modern assembly machinery can easily accommodate differences in test strip dimensions, by making a few mechanical adjustments and program selections for multiple strip widths. Well-designed equipment should include recipes for quickly changing strip width parameters that can be selected by the customer.

Retention pins and sockets should have generous lead-ins. The cassette bottom housing must have strip retention features that securely hold each strip after placement. This is essential to reliably pull each strip off the place head when it is placed into the cassette at high speed, and to prevent strips from flying out as the cassette is rapidly transported along the assembly process. These strip retention features should provide a tightly localized ‘bite’ into opposing edges of the strip in at least two locations along its length at each end, so as not to interfere with flow dynamics.

The retention features should be designed with lead-in features to “funnel” the strips into position upon final placement within the cassette.

Assembly equipment

For a reliable high-speed assembly process, it is essential that the strips be cut quickly, cleanly and without sticking to the shear or pick-and-place head. Kinematic developed a process whereby strips are sheared and immediately placed directly into the cassette in one smooth and continuous motion. This eliminates the need to cut the strip, pick it up and transport it to the cassette, then place it. It also helps to mitigate the problems of adhesives and electrostatic charges typically associated with these additional motions.

Adhesives are the bane of the lateral flow industry, being the most frequent cause of misfeeds, jams and downtime. Adhesives stick to cutting heads, guides and tracks – in fact, just about anything they touch – and require frequent cleaning. Minimizing aggressive, gummy adhesive in strip design is recommended.

Real-time inspection

No automated process can be considered complete without proper inspection of each assembly step. For best practice, Kinematic recommends using machine vision to inspect for each proper component placement prior to placing the top housing. This can also include inspection for strip damage or presence of remnant reject marks from upstream reject management errors. The finished assembly should then be checked again at final closure, to confirm proper closure height

For Further Information contact [email protected] or visit www.kinematic.com