Are there techniques to make CBDA oil more bioavailable ?

Yes and the availability is now!

The main hindrance to CBD’s sweeping benefits is its low bioavailability, resulting in the need of much higher dosage, and respectively money, to achieve the desired effects

Biochemist have been working hard to overcome this inherent obstacle, and have come up with a couple of methods that may not be full-on solutions, but still dramatically improve CBD’s bioavailability. Those methods revolve around the principles of nanotechnology, which refer to making particles much, much smaller, and therefore more easily absorbable, and tailor them to the idiosyncrasies of CBD.

Diet

But first, we should mention a somewhat surprisingly simple approach to making CBD more effective, one that has nothing to do with fancy technologies – diet.

A novel approach, yet as fundamental as consuming healthy levels of saturated fats in our body are necessary to carry CBD to its designated destination. (1) ( mid chain fatty acids like guacamole, MCT oils and GHEE )

Water-Soluble CBD

However, diet is the more limited approach to making the most of CBD. The real problem is that CBD is hydrophobic, meaning it doesn’t dissolve in water, which is one of the main reasons behinds its low bioavailability, considering how much of the human body is made up of water.

So, making CBDa more water-compatible, so to speak, basically equals making it more bioavailable and effective. A patented new process from CTFO/10 X Pure makes CBDA water-soluble – scientists have recently found a way to make CBDa completely dissolve into water,(10 X pure is the one company that has) therfore making it completely compatible with blood plasma, and respectively104% bioavailable.( more on this further in this article)

Scientist are currently taking 4 approaches to doing this.

Nanoemulsions

Nanoemulsions work by breaking up molecules to tiny, nanoscopic droplets, usually between 10 to 100 nanometers big, and using surfactants to bring down the surface tension of the water, so that the droplets can mix into it better.This technique of breaking up the molecules degrades one of the amazing benefits of CBD called the Entourage effect learn about the entourage effect here

Microemulsions

Microemulsions operate on the same principle as nanoemulsions, but are considered less effective – as far as emulsions are concerned, the smaller the particles, the better. Droplets, created through microemulsions, are usually between 100 and 5000 nanometers big.

Furthermore, microemulsions require the use of more surfactants, which can cause some side-effects with health implications, in addition to giving the product an unpleasant taste, usually bitter and/or soapy. Not a good option.

Liposomes

Liposomes are spherical structures, usually between 50 and 5000 nanometers big, made up of two hydrophilic layers and one hydrophobic bilayer, where CBD can be stored. It’s a very creative way to make CBD more water-friendly and deliver it into the body, kind of like sneaking it in under the disguise of the hydrophilic layers surrounding it.

However, as you might imagine, this process is quite complex and also requires lots of surfactants, in addition to working better with isolated cannabinoids as opposed to natural extracts.

Covalent Bonding( problem solved)

Water still remains one of main obstacles to CBD’s bioavailability and optimal effects, however, scientists are finding ways to bypass it, and one company has solved the riddle, they even figured out how to overcome it altogether.

A company called 10 X pure has solved this dilema by patenting a process that uses an oxygenation technique that utilizes covalent bonding to make the oil actually water soluble.

Jeremy Ducharme (founder of 10 Pure) has made this exceptional tool EXCLUSIVE to one company. Neurologist Dr. Steven Trobiani has said that 10 X pure is more effective than Celebrex and safer .In third part testing it was discovered that 10 X Pure protected CBDA

What was discovered with covalent Bonding was a serindipity of the cold process used to oxygenated the hemp molecules.This patented process preserves the CBDA, THCA and other acid forms of the molecules and componds. Independent third party testing showed that these most therapeutic properties of the hemp plant were preserved and actually pulled through tissue such as the Liver and Kidney tissues when independently tested.This ground breaking discovery has major implications for resolving health issues and because the CBDA remains vital in the blood and tissue more than ten times longer than regular CBD it can men lower dosage and cost.

References:

1. Elmes MW et al, Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), J Biol Chem.2015 Apr 3;290(14):8711-21. Epub 2015 Feb 9. Journal Impact Factor = 4.010; Times Cited = 64