Targeting IBS-C with Acacia Fiber and Probiotics: A 4-Week Clinical Evaluation

Objective: To investigate the effects and safety of Acacia fiber and probiotic supplements in alleviating gastrointestinal complaints in patients with constipation-predominant Irritable Bowel Syndrome (IBS-C).

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Study Design

Type: Randomized, double-blinded, placebo-controlled intervention trial

Duration: 4 weeks

Participants: Patients with IBS-C

Methods: Participants were randomly assigned to three groups, receiving either Acacia fiber, probiotic supplements, or a placebo. Changes in symptoms, treatment efficacy, and safety were measured and analyzed through questionnaires and clinical evaluations throughout the study.

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Key Findings

Symptom Improvement:

Patients receiving Acacia fiber and probiotic supplements showed significant improvements in gastrointestinal symptoms, including bloating, abdominal pain, and constipation.

These improvements were more pronounced compared to the placebo group.

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Safety and Tolerability:

Both supplements demonstrated good safety and tolerability profiles, with no serious adverse effects reported.

This indicates the feasibility of Acacia fiber and probiotics as long-term management options for IBS-C patients.

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Mechanistic Insights

Acacia Fiber: Works by enhancing beneficial gut microbiota, thereby improving the gut microbial environment and alleviating symptoms.

Probiotics: Help balance gut flora by reducing the proliferation of harmful bacteria and improving gut function.

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Conclusion

Acacia fiber and probiotic supplements significantly relieve gastrointestinal symptoms in IBS-C patients and have good safety and tolerability. These findings provide a scientific basis for developing new management strategies for IBS-C.

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Source: "Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial"