Study on rare sinonasal adenoid-cystic carcinoma

Here, we summarize the clinical, histopathological and molecular features of 14 rare sinonasal adenoid cystic carcinoma treated at the University Hospital Zurich, with long follow-up.

These carcinomas tend to relapse late, while the solid variant, high-grade transformation and sphenoid sinus involvement were unfavorable features.

Our cohort showed a high prevalence of MYB::NFIB gene fusion, which can also help to confirm diagnosis in cases with unusual morphology (such as the so-called metatypical AdCC).

Many thanks to Tina Mauthe and all those involved for this close and excellent collaboration to study this rare tumor disease.

Tina Mauthe Christian Meerwein, PD Dr. med. David Holzmann, Prof. Dr. med. Michael Soyka Simon Müller Ulrike Held Sandra Nicole Freiberger