Spotlight on Keto Research

This week’s “Spotlight on Keto Research” dives into cutting-edge studies that explore how ketogenic therapies are making waves in various health conditions—from boosting mitochondrial function in neurodegenerative disorders to improving heart health in diabetic patients. Here’s a closer look at some of the most fascinating findings:

??Phillips and Picard. Neurodegenerative disorders, metabolic icebergs, and mitohormesis

?? https://pubmed.ncbi.nlm.nih.gov/39242576/

This insightful review introduces a fresh perspective on neurodegenerative diseases, focusing on their shared hallmark—impaired mitochondrial function. It highlights the concept of mitohormesis, where mild mitochondrial stress could activate protective pathways, offering hope for new therapeutic approaches.

?? Laurent. Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder

?? https://pubmed.ncbi.nlm.nih.gov/39188977/

In a compelling case study, a 53-year-old woman with bipolar disorder II experienced significant improvements in mood, functionality, and overall quality of life after just five months on a ketogenic diet. The results suggest that keto-based therapies could be a game-changer for treatment-resistant depression.

?? Yang et al. Remodelling of the translatome controls diet and its impact on tumorigenesis

?? https://pubmed.ncbi.nlm.nih.gov/39143206/

This innovative study reveals how fasting and ketogenic diets activate a unique signaling pathway that influences ketone production by remodeling protein translation. These insights open up new avenues for enhancing the therapeutic potential of ketogenic therapies in cancer treatment.

?? Goldberg et al. Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

?? https://pubmed.ncbi.nlm.nih.gov/39162082/

By examining the body’s response to fasting, this study reveals how transcriptional cascades regulate gluconeogenesis and ketogenesis. The findings provide a clearer understanding of how the body balances energy production during periods of fasting.

?? Gopalasingam et al. Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction

?? https://pubmed.ncbi.nlm.nih.gov/39162035/

In a randomized crossover trial, researchers found that ketone ester supplementation improved cardiac output and reduced ventricular stiffness in patients with type 2 diabetes and heart failure with preserved ejection fraction. This offers a promising therapeutic approach for managing heart health in diabetic patients.

Find more research summaries on our website!

https://keto-mojo.com/research/

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