Spotlight on Keto Research: Jan 17th 2025
This week’s Spotlight on Keto Research highlights cutting-edge findings on how ketogenic interventions may support mental health and cardiovascular function, improve PCOS and neurodevelopmental disorders, and boost metabolic health. Dive into the details below!
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?? Klonek et al. Effects of a 12 Week Ketogenic Diet Intervention on Obese and Overweight Females with Glucose and Lipid Metabolism Disturbance
A ketogenic diet may improve glucose and lipid metabolism, especially in women with obesity. This study found that participants across all weight categories experienced reduced body mass, improved insulin sensitivity, and better lipid profiles after following a hypocaloric ketogenic diet for 12 weeks. The greatest metabolic improvements were seen in obese participants, suggesting that ketogenic diets could be particularly effective for managing obesity-related metabolic disturbances.
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?? Helvaci and Yildiz. Polycystic ovary syndrome as a metabolic disease.
Polycystic ovary syndrome (PCOS) is not only a reproductive disorder but also a complex metabolic disease. This review highlights how insulin resistance and metabolic dysfunction are central to PCOS, contributing to long-term health risks beyond fertility issues. Recognizing PCOS as a metabolic condition could reshape its management and open new avenues for treatment.
?? Kansakar et al. Exogenous Ketones in Cardiovascular Disease and Diabetes: From Bench to Bedside
Exogenous ketones may hold therapeutic potential in cardiovascular health and diabetes management. This systematic review highlights preclinical and clinical evidence suggesting that beta-hydroxybutyrate supports heart muscle cells (cardiomyocytes) and enhances pancreatic beta cell function, positioning it as a promising candidate for future cardioprotective and antidiabetic therapies.
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?? Perez-Kast and Camacho-Morales. Fasting the brain for mental health.
Intermittent fasting (IF) may improve mental health by reducing brain inflammation. This review highlights how IF modulates the gut microbiota, promotes ketone body production, and boosts brain-derived neurotrophic factor (BDNF), supporting neurogenesis and brain plasticity. These mechanisms suggest that IF could be a promising strategy for enhancing mental well-being beyond its known metabolic benefits.
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?? Omori et al. Exogenous ketone bodies and the ketogenic diet as a treatment option for neurodevelopmental disorders
Ketogenic diets and exogenous ketone supplements show promise as therapeutic options for neurodevelopmental disorders such as autism spectrum disorder and attention deficit hyperactivity disorder. This review highlights encouraging findings from preclinical and clinical studies, though variability in study designs underscores the need for further research.
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