Spotlight on Keto Research: Feb 21st 2025
This week’s Spotlight on Keto Research explores the application of ketogenic strategies in cancer treatment and cardiovascular health, the role of ketone metabolism in liver disease, and gut microbiota changes in post-bariatric patients on a ketogenic diet. Read below to find out more!
?? Bahrami et al. Fasting mimicking diet during neo-adjuvant chemotherapy in breast cancer patients: a randomized controlled trial study
A fasting-mimicking diet (FMD) during chemotherapy may enhance treatment response and reduce side effects in breast cancer patients. This randomized controlled trial found that patients who followed a FMD before and during chemotherapy experienced lower rates of severe vomiting and neutropenia, better blood cell preservation, and improved metabolic markers compared to those on a regular diet. The FMD group also showed a higher likelihood of tumor response, suggesting that strategic dietary interventions could complement cancer therapies.
?? Pala et al. Very low-calorie ketogenic diet reduces central blood pressure and cardiometabolic risk in post-menopausal women with essential hypertension and obesity: a single-center, prospective, open-label, clinical study
A very low-calorie ketogenic diet (VLCKD) may significantly reduce blood pressure and improve cardiometabolic health in postmenopausal women with obesity and hypertension. This study found that after six months, women following a VLCKD experienced significant and persistent reductions in central and brachial blood pressure, weight, and key metabolic markers, to a greater extent compared to those on intermittent fasting or a free diet.
?? Plaisance. Hepatic metabolism and ketone production in metabolic dysfunction-associated steatotic liver disease
Hepatic ketone production plays a crucial role in metabolic health, and its impairment may contribute to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This review highlights emerging evidence suggesting that reduced hepatic ketogenesis, particularly due to decreased expression of the key enzyme HMGCS2, is a driver of MASLD development. Understanding these metabolic disruptions could pave the way for new nutritional and pharmacological approaches to managing MASLD.
?? Ernesti et al. Impact of a very low-calorie ketogenic diet on metabolic and microbiota outcomes in post-bariatric patients and bariatric-Na?ve individuals: A comparative pilot study
A very low-calorie ketogenic diet (VLCKD) could support weight loss in both post-bariatric and bariatric-na?ve individuals, though metabolic and gut microbiota responses may differ. This pilot study found that while both groups achieved significant weight loss, bariatric-na?ve participants showed a higher degree of improvement in insulin resistance and triglycerides. The VLCKD also altered gut microbiota composition in both groups, with more pronounced diversity shifts in bariatric-na?ve participants. These findings suggest that tailored dietary strategies may be needed to optimize metabolic outcomes in post-bariatric patients.
?? Soni et al. Therapeutic potential of ketone bodies on exercise intolerance in heart failure: looking beyond the heart
Ketone bodies may help improve exercise tolerance in heart failure by supporting not only the heart but also the vasculature and skeletal muscle. This review highlights emerging evidence that ketone therapy, particularly through ketone esters, may enhance cardiovascular function while also addressing vascular and muscular impairments that contribute to reduced exercise capacity in heart failure. Understanding these broader metabolic effects could expand the available therapeutic options beyond traditional cardiac-focused treatments.
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Metabolic Health Advocate. Founder at Metabolic Multiplier
1 周Paul Seth a metabolic component to breast cancer treatment?