Speed Up Atopic Dermatitis Drug Development with Biocytogen’s Fully Human Antibody Innovations
Atopic Dermatitis (AD) is a chronic inflammatory skin condition characterized by intense itching, erythema, and scaly lesions, often leading to painful sores. It is also associated with comorbidities such as cardiovascular disease, mental health disorders (including depression and anxiety), and sleep disturbances. As of 2022, AD affects an estimated 320 million adults worldwide, with 30% experiencing moderate to severe cases. For these patients, conventional topical treatments often provide limited relief, underscoring the need for advanced therapies.
Targeted antibody therapies?have emerged as a promising approach for moderate to severe AD, particularly for patients unresponsive to conventional treatments. These therapies target key pathways in AD pathogenesis, such as?OX40?and?IL-4R. OX40, a co-stimulatory molecule expressed on activated T cells, plays a crucial role in driving inflammation, while IL-4R mediates signaling for IL-4 and IL-13, two key cytokines involved in AD-related inflammation. Dupilumab, an IL-4R inhibitor, has demonstrated significant efficacy in clinical trials. Meanwhile, emerging OX40-targeting therapies are under investigation, offering potential for broader immune modulation.
Biocytogen?offers a portfolio of high-affinity, high-specificity AD-related antibody assets, developed through our proprietary fully human?RenMice??antibody discovery platform.
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??OX40 BpAb (BCG028) from RenLite KO
Highlights of our assets:
Superior?in vivo?efficacy of BCG028-IgG1 and BCG028 in a mouse GvHD model
BCG028 exhibited a prolonged serum half-life compared to benchmarks in humanized FcRn mice
BCG028 exhibited robust ADCC activity against OX40+ T cells
Our AD-Related Projects (Partial List)
In addition to the projects listed above, we have several others currently in development—stay tuned for updates!