Solentim Ecosystem Updates
Dear Cell Line Development Community,
Welcome to the new edition of the Advanced Instruments’ Solentim Ecosystem Newsletter on LinkedIn! ?We are excited to bring you the latest insights and updates in the world of Cell Line Development for cellular, gene, and protein therapies.
Streamline your CLD workflow with STUDIUS?1.6 Software Update
To provide you with the best possible experience using your Solentim Instruments (VIPS? PRO, Cell Metric? X, and ICON?) we have updated the STUDIUS software to version 1.6.
What’s new?
The Smart Choice for Protein Biologics Screening, Now with Glycan Profiling Capabilities - Discover the ICON
The Solentim ICON is a solution for clonality assurance, colony outgrowth quantitation, and titer assessments. Advanced Instruments are now partnered with PAIA Biotech GmbH for a cutting-edge combination facilitating the semi-quantitative screening of critical glycan features. This means scientists can not only select the highest producing clones during CLD, but also those with the best quality proteins.
Struggling to Detect Complex Mesenchymal Stem Cell (MSC) with a complex Morphology?
MSCs show an increasing promise in cell therapy as an alternative to iPSCs.? However, due to their intricate morphology, MSCs can pose a challenge when it comes to accurate cell detection at both single-cell and clonal colony stages. Our new AI-based algorithm enables extremely precise detection of complex MSC morphology from single cell to full colony outgrowth using STUDIUS software.
Not Sure How To Go About Clonality Assurance In Your Antibody Production Workflow?
This fantastic blog by ProteoGenix provides a detailed guide to our VIPS PRO technology, explaining how it can transform and accelerate stable cell line development.
Highlights:
New & Improved Formulation of InstiGRO? CHO PLUS!
Application Note
Ensuring cells receive the metabolites they need is fundamental for success. While cell culture mediums do their best, cells often need a little extra support from cell culture supplements to overcome stressful processes, such as single cell isolation. Advanced Instruments’ original InstiGRO CHO PLUS was developed in 2019 to promote the growth of healthy clonal colonies. Our new and improved formulation allows further optimization of cloning efficiencies and average colony size, allowing scale up to commence at earlier time points. Check out how UGA Biopharma GmbH , an international team of experts specializes in the development of monoclonal cell lines for the manufacture of biologics and biosimilars, are using InstiGRO CHO PLUS to streamline their cell line development projects.
Why Did CleanCells Choose VIPS PRO to Support Their CLD Services?
Deciding on the right technology to support a complex and versatile offering can be a difficult decision to make. Read our blog post, whereby, Alexis Rossignol, PhD (Analytical Development & Validation Project Manager) discusses why Clean Cells opted for clonality assurance and future-proofing their GMP offering by opting for our VIPS PRO platform.
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Missed Any of our Recent Webinars or Demos?
Addressing the Issue of Genomic Stability in iPSCs: New Approach for Restoring Cell Lines
Did you know that up to 30% of iPSCs cultures experience issues with genomic stability? This in turn will impact the therapeutic use of iPSCs in cell therapy by not only extending project timeline but also adding a significant cost.
Watch our webinar with Clare Richard from Cellected Limited during which we will discuss the best strategies for quality control of iPSCs and, how mosaic genomic abnormalities can be rescued using the cutting-edge technologies from Advanced Instruments as a part of Cellected’s innovative RESCUE services. ?
AI and Robotics in Cell Line Development: Enhancing Efficiency and Accuracy
In the specialized field of cell line development, researchers are constantly grappling with the challenges of maintaining high-throughput efficiency and ensuring clonality, often constrained by manual processes and the intricacies of analyzing sophisticated cell lines. In this webinar, the attendees gain insight into the latest advancements in high-resolution multi-plane whole well imaging and the impact of artificial intelligence (AI)-powered image analysis on clonality decisions and optimal close selection.
Whether the aim is to expedite biopharmaceutical production or advance novel cell-based therapies, the expert speakers share their insights into digital and physical automation to enhance research outcomes and ensure reproducibility and scalability.
They also explore how Cell Metric X (CMX), with its foundation in industry-leading innovation, is redefining efficiency and accuracy in cell line development, addressing the sector’s critical needs and propelling biotechnological advancements.
Maximizing Cloning Success: Combining Automation with Cell Supplements for the Best Results.
Struggling with seeding efficiency and clonal outgrowth of your CHO cells? Not sure how to go about clonality assurance?
We can help!
In this webinar, we discuss and demonstrate the best strategies to achieve high seeding efficiency and clonal outgrowth without any compromise on cell health.
Mastering Clonality and Improving Cell Growth with Cell Metric X HT and InstiGRO
As the gene therapy sector expands, so does the need to enhance cell line development (CLD) techniques, particularly in the establishment of stable, high-yield producer lines. A pivotal step in this process is proving clonality, and ensuring the growth and stability of clones, both of which come with technical challenges.
This webinar will showcase the Cell Metric X HT’s ability to capture evidence of clonality, automate clonal outgrowth analysis, and track colony growth rates using Artificial Intelligence (AI). We will also examine the ability of the InstiGRO HEK and InstiSHAKE? HEK cell culture supplements to enhance the clonal outgrowth and expansion of HEK293 cells to enable scalable manufacture of novel gene therapies.
Closing Remarks
Thank you for reading this edition of Solentim Newsletter. We hope you found it informative and engaging. If you have any feedback or suggestions for future issues, we’d love to hear from you. Stay tuned for our next edition, and don’t forget to follow us on LinkedIn for more
updates.
Best regards,
Solentim Team
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