Simulating the human brain in a computer ??, scalable querying of cell atlases ???, NGS simulator for assay design ??

Simulating the human brain in a computer ??, scalable querying of cell atlases ???, NGS simulator for assay design ??

Bioinformer Weekly Roundup

Stay Updated with the Latest in Bioinformatics!

Issue: 5 | Date: 1 September 2023

?? Welcome to the Bioinformer Weekly Roundup!

In this newsletter, we curate and bring you the most captivating stories, developments, and breakthroughs from the world of bioinformatics. Whether you're a seasoned researcher, a student, or simply curious about the intersection of biology and data science, we've got you covered. Subscribe now to stay ahead in the exciting realm of bioinformatics!

?? In The Spotlight

Interested in understanding the mutational signatures present in human cancer data? Delve into our most recent article, where we introduce the fundamental principles of mutational signature analysis, accompanied by a practical step-by-step guide. Click on the image below to access the full article.

Signatures of mutational processes in human cancer | Zifo Bioinformatics

?? Featured Research

De novo detection of somatic mutations in high-throughput single-cell profiling data sets | Nature Biotechnology

A new algorithm called SComatic detects somatic mutations in single-cell genetic data accurately without needing matched DNA data, helping study cancer evolution and cell changes in individual cells. It works well even for complex tissues and outperforms other methods in mutation detection.

Scalable querying of human cell atlases via a foundational model reveals commonalities across fibrosis-associated macrophages | bioRxiv

A framework called SCimilarity has been developed to help researchers understand and compare cell types in single-cell RNA sequencing studies. SCimilarity creates a common representation for cell profiles, making it easier to find connections between cell states and diseases across different datasets.

??? Latest Tools

Projecting RNA measurements onto single cell atlases to extract cell type-specific expression profiles using scProjection | Nature Communications

A method called scProjection has been developed to accurately convert multi-modal single-cell RNA measurements into detailed single-cell gene expression profiles by utilizing deeply sequenced scRNA-seq atlases.

ARA: a flexible pipeline for automated exploration of NCBI SRA datasets | GigaScience

The ARA pipeline is a user-friendly and flexible tool for exploring SRA database records using established NGS data processing tools, granting control over analysis steps and producing comprehensive summary files.

Flow: a web platform and open database to analyse, store, curate and share bioinformatics data at scale | bioRxiv

Flow is a web-based platform designed to help biologists overcome challenges in processing and sharing sequencing data. It offers a user-friendly interface and API that connects bioinformatic analysis and databases, while ensuring data security and control.

Sandy: A user-friendly and versatile NGS simulator to facilitate sequencing assay design and optimization | bioRxiv

Sandy is an open-source simulator that generates synthetic reads mimicking DNA or RNA sequencing across different platforms. It's user-friendly and efficient, simulating various features like sequencing quality and genomic variations.

?? Community News

The Nextflow Podcast - Episode 21: Live debugging Nextflow, Ambassadors & Training | YouTube

Ever wanted to peer inside Nextflow as it runs your pipeline? We play with an interactive debugger to do just that. Also, a first peek at a new Nextflow Ambassador program, plus a revamped hands-on Nextflow training course.

Europe spent €600 million to recreate the human brain in a computer. How did it go? | Nature

The Human Brain Project wraps up in September after a decade. Nature examines its achievements and its troubled past.

?? Upcoming Events

UCam/EBI Collaboratorium, Cambridge | 21 September 2023

The University of Cambridge and EMBL-EBI are hosting a joint one-day computational biology meeting to explore collaborative research and future opportunities between the two institutions.

AI and Biology, Heidelberg and Virtual | 12 - 15 March 2024

EMBL Heidelberg is organising the inaugural 'AI and Biology' symposium, which aims to facilitate collaborative interactions among AI researchers specialising in various subfields of biology.

Single Cell Analyses Meeting, New York and Virtual | 8 - 11 November 2023

This meeting assembles leaders in the field, together with junior faculty, postdoctoral fellows, and graduate students, to discuss new, cutting-edge developments and techniques in single-cell analysis in bacterial, yeast, plant, and animal systems.

NHS-R Online Conference Talks 2023, Virtual | 9 - 11 October 2023

The NHS-R Community will be hosting its annual conference, including pre-conference online talks, online workshops and the main conference. The aim of the NHS-R Community is to promote the use of R (+ other open source solutions) to the health and care sector.

?? Educational Corner

Harvard Biostatistics 260 Introduction to Data Science | GitHub

Harvard Biostatistics 260 Introduction to Data Science starts next week. Course notes and exercises, updated weekly, are publicly available here.

Linear Regression - A Visual Introduction To (Almost) Everything You Should Know | GitHub

This article focuses on the use of Linear Regression, a powerful model in machine learning, for predicting numerical outcomes based on independent variables.

Machine Learning University | AWS

Machine Learning University (MLU) provides anybody, anywhere, at any time access to the same machine learning courses used to train Amazon’s own developers on machine learning.

?? Connect with Us

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Disclaimer: The information provided in this newsletter is for educational and informational purposes only and does not constitute professional advice.

Editor: James Ashmore | Contact: [email protected]

Copyright ? 2023, Bioinformer Weekly Roundup. All rights reserved.

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