SHAPE Reagents for RNA Structure Analysis

SHAPE (Selective 2'-Hydroxyl Acylation and Primer Extension) reagents are used for the analysis of local nucleotide dynamics in RNA developed based on isatoic anhydride.

TCI offers 6 products with different characteristics, including?N-Methylisatoic Anhydride (Product No.?M0743), which has been widely used as a SHAPE reagent.

M0743 ??N-Methylisatoic Anhydride

M3578 ??1-Methyl-7-nitroisatoic Anhydride

M3589 ??1-Methyl-6-nitroisatoic Anhydride

N1245 ? ?5-Nitroisatoic Anhydride

B0835 ? ??Benzoyl Cyanide

A0694 ? ??N-Acetylimidazole

Each SHAPE Reagent has its own Characteristics, to know the details please visit: https://www.tcichemicals.com/IN/en/product/topics/SHAPE_reagents