Self-activating chitosan-based nanoparticles for sphingosin-1 phosphate modulator delivery and selective tumor therapy
MirAhmad Mazloomi
M. Sc., Medical Biotechnology Cancer research, Nanoparticles - Drug Delivery Systems- Python - Cancer Stem Cells- In vivo experiments - Particle Engineering for Pulmonary
The research titled "Self-activating chitosan-based nanoparticles for sphingosin-1 phosphate modulator delivery and selective tumor therapy" has been published in the International Journal of Biological Macromolecules. This study reports the initial findings on the synthesis of hypoxia-responsive chitosan-based nanoparticles that meet specific physical and chemical conditions. These nanoparticles have the unique capacity to activate and selectively generate high-charge nanosized tumor-penetrating chitosan nanoparticles. The formula can selectively deliver Fingolimod to the inner part of the tumor, minimizing its adverse effects and enhancing its ability to eradicate persistent TNBC tumors.
I am really pleased to have made a meaningful contribution to this study. I was responsible for conducting in vivo experiments in this project and also contributed to some parts of the nanoparticle synthesis process.
#chitosan
#chitosan_nanoparticles
#cancerstemcells
#CSC
#hypoxia_responsive
#Fingolimod