Sea4Pain: What is it and why should you care
We are developing a first-in-class therapeutic analgesic drug derived from a marine sponge found on Sagres's coast.
A medicine that leverages the evolved chemistries in the ocean, to offer a new approach to treat chronic pain.
The Science Behind the Compound
To develop a safe and effective treatment, one must deeply understand disease mechanisms. Intensive research on the mechanisms of pain signalling and perception enabled us to harness the sea's potential.
A novel mode of action for managing pain perception and novel chemistries capable of modulating such signals.
It targets specific ion channels expressed in pain-sensing neurons of the peripheric nervous system. These channels are crucial in modulating neuronal activity, which is key to pain perception.
By modulating them, we can effectively "switch off" pain-induced hyperactivity of neurons. It abolishes pain, acting exclusively on neurons actively reporting pain.
Sea4Pain has shown remarkable efficacy in six chronic pain models, opening a vast potential of medical applications. Those include:
A Non-Opioid Solution for Chronic Pain
A significant advantage is its non-opioid mode of action.
Opioids, while effective, come with severe side effects and high addiction potential.
In preclinical studies, our therapeutic provided pain relief equivalent to Morphine at significantly lower doses without numbness or non-specific side effects.
No signs of toxicity have been detected so far, and chemical optimization has further improved its efficacy and simplified chemical synthesis.
Unique Mode of Action
Pain involves complex alterations in the processing and conduction of electrical signals from the peripheral nerves to the central nervous system (CNS). In the peripheral nerves, pain-sensing neurons carry nociceptive input to the CNS.
In normal conditions, these neurons do not have spontaneous firing (electrical) activity. In chronic pain conditions, however, this neural network becomes excessively and persistently excitable.
Sea4Pain specifically inactivates hyperactive potassium channels and derived signaling. It does not act centrally in the brain. This precision reduces off-target side effects commonly seen with other analgesics, such as dizziness, nausea, and drowsiness.
The ability to "switch off" this hyperexcitability in pain-sensing neurons is a key factor in its effectiveness and safety.
Easy Administration and Cost-Effective Production
As a small molecule, Sea4Pain is easy to synthesize and can be administered by different routes, including orally. This makes it a practical and patient-friendly solution. Its simplified chemical synthesis facilitates scale-up.
Commercial Viability and Future Prospects
This elected compound has already attracted interest from international pharmaceutical companies that will in-license it after first-in-human clinical trials.
Our strong patent portfolio ensures the commercial viability of the medicine, covering both the chemical compound and its novel mode of action.
With its unique combination of efficiency and safety, this compound is poised to revolutionize chronic pain treatment.
Our goal is to bring this groundbreaking solution to market and improve the quality of life for millions of chronic pain sufferers worldwide.
Join Us in Our Mission
We know Sea4Pain's transformative power to those who need it most. Together, we can make a significant impact on millions of lives.
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