Science News | Novel AI-based Software Allows Quick, Reliable Imaging of Proteins in Cells
Washington [US], May 16 (ANI): "TomoTwin paves the way for automated identification and localization of proteins ..directly in their cellular environment expanding the potential of cryo-ET," adds co-first author Gavin Rice. Cryo-ET offers the ability to reveal the basis of life and the origins of diseases by deciphering how biomolecules work within a cell. ..
In a cryo-ET experiment, scientists utilise a transmission electron microscope to create 3D images of the cellular volume containing complicated biomolecules, known as tomograms.To obtain a more detailed image of each protein?they average as many copies as feasible, similar to how photographers capture thesame image at multiple exposures in order to integrate them in a precisely exposed image eventuallyBefore averaging the proteins it is critical to correctly identify and locate them in the image "Scientists can obtain hundreds of tomograms daily,"Rice says, "but we lacked tools to fully identify the molecules within them."
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