Science Brief - February 2025
The planet Uranus, which is believed to have superionic ice.

Science Brief - February 2025

New clues about superionic ice, possibly present in giant planets

Scientists from CEA have solved previous discrepancies over the temperature at which superionic ice forms under extreme planetary interior conditions using the the ESRF’s beamline ID27. The study reveals a clear structural signature of the superionic transition, enabling its precise location in the phase diagram of water ice. The results will enable a greater understanding of this intriguing high-pressure and high-temperature form of ice.

Journal: Physical Review Letters

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Variability analysis of BmrA in the IF conformation with several ligands. A/ 3DVA analysis of E504Aapo in several components, resulting in 20 maps each. Models built by variability refinement in the maps are represented in cartoon and colored from blue to cyan, with view from the NBDs. The main movement is represented on the structure with black lines representing the NBD rotation and the colored arrows depict the movement and its amplitude. B/ same as A/ for E504AR6G, colored from red to yellow. C/ same as A/ for E504AH33342, colored from green to white.

New insights into the link between protein dynamics and antibiotic resistance

Antibiotic resistance takes place when ABC transporters remove antibiotics from the bacterial cell, preventing their killing action. Scientists from the CNRS have gained insights into the mechanism of an ABC transporter, BmrA, using the CRYO-EM at the ESRF.

Journal: Nature Communications

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?Nano-XPCT 3D rendering of the longitudinal view of one crypt of SAMR1 mouse. The epithelial layer of the crypt has been rendered in green. The Paneth cells are colored in yellow and the goblet cells in blue. Scale bars, 5 μm. Credits: A. Cedola

The gut-brain connection in Alzheimer’s unveiled with X-rays

Scientists led by the Institute of Nanotechnology in Italy, in collaboration with the ESRF, have discovered how X-ray micro- and nano- tomography can provide clues on the processes that link the gut neurons with those in the brain and may trigger Alzheimer’s.

Journal: Science Advances

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How specific bacteria 'steals' iron from our blood during infections

Researchers have revealed how?Staphylococcus aureus?bacteria extract iron from hemoglobin – a process crucial to their survival during infections. Using a novel time-resolved X-ray solution scattering (TR-XSS) technique at the ESRF, they have identified the full sequence of protein–protein interactions during this iron ‘theft’. The findings open possibilities for developing pharmaceuticals to combat antimicrobial-resistant strains of S. aureus.

Journal: Nature Communications

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User Gabriel Büchel and Dimitrios Bessas (ESRF scientist) setting up the experiment on the new beamline ID14.

First ID14 results analyse potential anticancer complex

Scientists show that Nuclear Resonance Scattering of synchrotron radiation can provide valuable information in how osmium complexes interact with cells in potential anticancer treatments. It is the first experiment of the new ID14 beamline.

Journal: Science Advances

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The ESRF User Meeting 2025 brings together our scientific community (video)

This year, the ESRF User Meeting brought together 340 participants from 21 countries to the ESRF. In three days, users and ESRF scientists attended keynote lectures, poster sessions, microsymposia and tutorials.

Check out our video!



Aram Bugaev (left) receivin the prize from the chair of the User Organisation, Guillaume Morard.

Aram Bugaev wins the ESRF Young Scientist Award 2025

Aram Bugaev , researcher at the Paul Scherrer Institute, is the recipient of the ESRF Young Scientist Award 2025 for “providing significant advances in experimental and theoretical X-ray spectroscopy offering new insights into in-situ/operando homogenous and heterogeneous catalysts’ structures”.


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