Save Lake Balkhash International Research and Brain Basics.

In my global research SLBH, 4Est, H - Water, Mangroves and Hydrogen which is linked to multiple sectors and industries I additionally present studies to identify the neural network that is directly involved in the development process of human motor system and verbal logical memory functions among infants and toddlers who live in arid and semi-arid geographies ( Central Asia, UAE, Saudi Arabia, etc.) Starting from the January 2024 I made several discoveries, such as the underrated importance of the involvement of both hands in writing process and the influence of the geometry of writing on the formation of motor skills and verbal logical memory among infants and toddlers - https://figshare.com/articles/journal_contribution/Khalifa_Award_Application_Work_Document_by_Dr_Aizhan_Ussenaliyeva_Founder_and_CEO_of_Save_Lake_Balkhash_International_Research_Project_Correlation_between_water_sector_and_brain_health_/25670649

In continuation of my research I study potential ways of the Alzheimer's disease treatment, considering early age education factors, diet, climate conditions, physiology and social routines. Based on my most recent studies I rediscovered the increasing negative impact of such harmful physical factors, as noise, vibration, electromagnetic radiation that sometimes cause irreparable harm to public health and the economy by affecting brain health directly and reducing manual labor productivity by 30 percent and and mental productivity by 60 percent.

That drove my scientific attention to the brain health even more robustly. Especially considering water as a common denominator for the fields of health, water management. industrial innovations and education.

The following are my research findings, based on medical expert interviews, numerous literature reviews, experiments, professional observations and discoveries.

Based on the nature of cerebral circulatory disorders, the following are distinguished: a) Initial signs of insufficient blood supply to the brain b) Acute cerebrovascular accidents ( CVA ) - transient disturbances, intrathecal hemorrhages, strokes c) Сhronic slowly progressive disorders of cerebral and spinal blood supply ( dyscirculatory encephalopathy and myelopathy ). Clinical symptoms of initial manifestations of insufficiency of blood supply to the brain are those that appear after strenuous intellectual and / or physical work, staying in a stuffy room: headache, dizziness, noise in the head, decreased performance and sleep disturbance. Focal neurological symptoms in such cases are usually absent or represented by scattered microsymptoms.

To diagnose the initial manifestations of insufficient blood supply to the brain, it is necessary to identify objective signs of atherosclerosis, arterial hypertension, vasomotor dystonia and exclude somatic pathology and neurosis. Acute cerebrovascular accidents as I have mentioned above include transient circulatory disorders in the brain and strokes. Transient cerebral circulatory disorders are manifested by focal or general cerebral symptoms ( or a combination thereof ) lasting less than one day. Most often they are observed in atherosclerosis of cerebral vessels, hypertension and arterial hypertension. Among acute cerebrovascular accidents, transient ischemic attacks and hypertensive cerebral crises are distinguished. The first are characterized by the appearance of focal neurological symptoms ( weakness and numbness of the limbs, difficulty in speaking, static disorders, etc. ) on the background of mild or absent cerebral symptoms. On the contrary, hypertensive cerebral crises are characterized by a predominance of cerebral symptoms ( headache, dizziness, nausea, vomiting ) over focal ones, which sometimes may be absent. Acute cerebrovascular accident in which focal neurological symptoms persist for more than one day is considered a stroke. Acute disorders of venous circulation in the brain also include venous hemorrhages, thrombosis of the cerebral veins and venous sinuses. Chronic cerebrovascular accidents are the result of progressive insufficiency of blood supply caused by various vascular diseases which makes cerberal circulation the key area to analyse in the study of brain pathologies and therapy. According to Dr. Santiago Ramón y Cajal in the treatment of cerebrovascular accidents, timely recognition of the initial manifestations of brain blood supply insufficiency in which pathological changes may still be reversible, is highly critical. Carrying out preventive therapeutic measures helps stop the progression of cerebral blood supply insufficiency. Those therapeutic measures should be aimed at the normalization of work and rest regime, selection of a rational diet with strong emphasis on improving the cerebral hemodynamics, metabolism and microcirculation.

To be continued.

Zayed Sustainability Prize

T?llberg Foundation

耶鲁大学 Yale School of the Environment Yale School of Medicine