SARS CoV-2 Virus Hijacks ACE-2 Receptors!
Susen Trail, CIH
Safety Management Software Content Writer and Onsite Safety and Health Services
This week we’re going to talk about the ACE 2 receptor, it’s normal function in the body and what happens when the SARS CoV-2 virus binds to it.?
My all-time favorite course was Biochemistry!? It broke down how everything in the body works, how it creates the chemicals that create energy, how the energy is used, the triggers and the brakes for all of the processes.? It was like a tour of a fine watchmaking workshop where you saw how all the gears meshed in different ways to create a machine that tracked time.? I used the knowledge I got from my Biochemistry class in my Molecular Biology classes and then in my research using DNA and RNA.? Consequently, I’m going to have to try not to geek out over the hormones and enzymes and systems our body’s use to regulate blood pressure.? I’ll include links to my sources so you can get more information.
The mechanism of infection for SARS CoV-2, the virus that causes COVID-19, is the use of a spike protein on the viral cell wall that is compatible with the ACE-2 receptor on cell walls in the body.? Think of the spike as a size 8 foot and the ACE-2 receptor as a size 8 shoe.? The virus connects to the cell via the ACE-2 receptor to gain access to the cell.? Then the RNA hijacks the cell’s protein building process to churn out new viruses, each with their own spikes to repeat the process.
Which begs the question, what was the ACE-2 receptor supposed to be doing?? What other feet fit the size 8 shoe? Is it important?
?The Renin-Angiotensin-Aldosterone System (RAAS) regulates blood pressure (force against the blood vessel’s walls from the heartbeat) by regulating the width of your blood vessels and fluid balance in the body through hormones, proteins, and enzymes.
Enzymes are proteins that trigger chemical reactions in your body that build up or break down substances.
2. The liver produces a protein called Angiotensinogen.? Renin is transported to the liver.
3.? Renin breaks Angiotensinogen down into pieces, one of which is a hormone called Angiotensin I.
Hormones carry information through the blood to organs, muscles, and other tissues that signal what is to be done.
4.?When it gets to the lungs and kidneys the Angiotensin-Converting Enzyme (ACE) breaks Angiotensin I into smaller pieces, such as Angiotensin II.
?Angiotensin II helps maintain blood volume and transport to vital organs by providing the information that it is time to:
o? Release of Aldosterone, a hormone that retains sodium and water in the kidneys
o? Trigger thirst and desire for salt through the hypothalamus
o? Stimulating the release of antidiuretic hormone to retain water.
The usefulness of Angiotensin II is temporary, you don’t want it hanging around to:
?The ACE-2 receptor breaks down Angiotensin II into 2 proteins that counteract the effects of Angiotensin II.? The receptors are present in many cell types and tissues, including the heart, kidneys, lungs, blood vessels, liver, gastrointestinal tract.? It is present in epithelial cells that line certain tissues and create protective barriers.? The ACE-2 receptor also plays a key role in:
?What the ACE-2 receptor is currently best known for is being the receptor for the SARS-CoV-2 which regulates Angiotensin II.? Studies show that when ACE 2 receptors have been removed from the cell surface, and are floating in the blood stream they are a biomarker for hypertension and heart failure.? By reducing the availability of functioning ACE 2 receptors the quantity of available Angiotensin II does not decrease and will continue to constrict blood vessels, etc., making the heart work harder to get blood to organs and muscle tissues.
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?“COVID-19 vaccines increase the endogenous synthesis of SARS-CoV-2 spike proteins. Once synthetized, the free-floating spike proteins circulate in the blood, interact with ACE2?receptors and resemble the pathological features of SARS-CoV-2 ("Spike effect" of COVID-19 vaccines). It has been noted that an increased catalytic activity of POP/PRCP [an alternative Angiotensin II breakdown pathway] is typical in elderly individuals with comorbidities or previous cardiovascular events, but not in younger people. Thus, the adverse reactions to COVID-19 vaccination associated with Ang II accumulation are generally more common in younger and healthy subjects. Understanding the relationships between different mechanisms of Ang II cleavage and accumulation offers the opportunity to close the pathophysiological loop between the risk of progression to severe forms of COVID-19 and the potential adverse events of vaccination.”1
?I started out this article with the theory that if:
1.?????? The spike on SARS Cov-2 virus is compatible with the ACE-2 receptor.
2.?????? The mRNA vaccines create a lot of spikes.
Then one or more of the following may happen:
a.?????? Vaccine generated spikes will interact with the immune system and create an antibody (a free-floating size 8 shoe) for the SARS CoV-2 viral spike.
b.?????? Vaccine generated spikes will interact with the immune system and create an antibody for any size 8 foot that interacts with the ACE-2 receptor.
c.?????? Vaccine generated spikes will bogart a lot of the ACE2 receptors leaving Angiotensin II active.
?On Thursday, June 10th, 2021, Dr. Tom Shimabukuro, Deputy Director of the CDC’s Immunization Safety Office made a presentation to a Food and Drug Administration advisory group where he stated that there was 230% higher incidence of increased heart size among people under 30 years old who received the second dose of mRNA vaccine. ?After the presentation Dr Cody Meissner, Chief of Pediatric Infectious Diseases at Tufts Children’s Hospital, Boston, stated “it is hard to deny that there’s some event that seems to be occurring in terms of myocarditis.”2
?Myocarditis is an inflammation of the heart muscle that affects the heart’s ability to pump blood.? Symptoms include chest pain, shortness of breath, and rapid or irregular heartbeat.? If left untreated it could cause heart failure, and blood clots can form resulting in a heart attack, or stroke.?
As stated above, increased heart size is one of the adverse health effects of unregulated Angiotensin II.
Please note that there is very little information on ACE-2 Angiotensin II pathways in children mostly regarding adolescent hypertension.
?The articles below were used in the research for this article:
?
COVID-19, vaccines and deficiency of ACE2 and other angiotensinases. Closing the loop on the "Spike effect" - PMC (nih.gov)
Industrial Hygiene Practice Leader at F&R; I help you protect people and property throughout the process of property acquisition, development, and use.
7 个月Do we know or can we project the longer term impact of this effect on young people? After some time following vaccination, do the receptors "free up" or behind available to break down Angiotensin II?