Revolutionizing antibiotics: How green chemistry is shaping a Sustainable future for India's pharma industry:

Green chemistry, often referred to as sustainable chemistry, is a scientific approach focused on designing products and processes that minimize the generation and use of hazardous substances.

?This approach, focused on minimizing environmental impact throughout the chemical lifecycle, green chemistry emphasizes sustainable practices that can address issues like pollution, resource depletion, and climate change.

?As industrial-pharmaceutical processes continue to grow globally, traditional chemical processes have significant environmental impacts, including pollution and resource scarcity. Green chemistry offers a pathway to reduce harmful by-products and to create safer, more sustainable chemical processes that align with today’s environmental and regulatory demands.

The role of enzymes in manufacturing β-Lactam antibiotics:

In green chemistry, enzymes serve as biocatalysts, enabling specific reactions under mild conditions, reducing the need for toxic reagents, and minimizing waste. Enzymes like penicillin acylase are commonly used for the acylation of 6-aminopenicillanic acid (6-APA) and 7-amino cephalosporanic acid (7-ACA), which are key intermediates in the synthesis of penicillin and cephalosporin antibiotics.

The enzymatic route in beta-lactam antibiotic manufacturing is a more sustainable alternative to traditional chemical methods. Enzymes, function efficiently at mild temperatures and neutral pH, significantly reducing the environmental footprint.

Advantages of green chemistry synthesis (enzyme) Beta-Lactam antibiotic manufacturing:

• Reduced environmental impact
• Energy efficiency
• Specificity and yield
• Reduced waste

In summary, the integration of green chemistry with enzyme catalysis in beta-lactam antibiotic manufacturing represents a promising step toward more sustainable antibiotics manufacturing. By reducing environmental impact, optimizing resource use, and enhancing product yields, this approach can help meet current and future needs for antibiotics while preserving environmental and human health.

Globally, enzyme biocatalysis is seeing advancements and could potentially make a greater impact on antibiotic production if scaled and adopted more widely.

?Indian antibiotic industry to improve sustainability, several strategies can be explored. This includes optimizing biocatalyst stability to handle industrial production conditions, developing enzyme variants for more efficient reactions, and investing in greener infrastructure. Community insights and industry collaboration can further support the shift towards these sustainable practices.

What are some approaches you think could enhance sustainability in this sector?

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Apitoria Pharma Private Limited

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Karnataka Antibiotics & Pharmaceuticals Limited, Peenya, Bangalore