Rethinking Evolution: The Electronic Biology Perspective

Evolution is one of the most remarkable narratives in biology, traditionally described through genetic variation and natural selection. But what if the story extended beyond DNA sequences and mutations, into the fundamental realm of electrons? Albert Szent-Gy?rgyi, a pioneer in electronic biology (https://electronicbiology.org/), hinted at this paradigm, suggesting that life’s essence resides in electron behavior and interactions. Here’s how electronic biology reshapes our understanding of evolution:

1. The Evolutionary Paradox

Szent-Gy?rgyi described evolution as a balance between complexity and stability. Mutation drives innovation, but excessive instability threatens survival. Life’s molecular architecture stability hinges on coherent electron flow, ensuring resilience amidst change.

2. Oxidation: A Hidden Driver of Evolution

Oxygen, a potent agent of transformation, reshaped life during the Great Oxidation Event, enabling aerobic metabolism and complex multicellular life. However, oxidation also introduced challenges, such as reactive oxygen species (ROS), which damage biomolecules. Evolutionary innovation, including antioxidant systems, emerged to balance this double-edged sword.

At the molecular level, oxidation creates “free space” in conducting bands, enhancing electron mobility. This shift diversifies the functionality of proteins and DNA, driving complexity. For instance:

• Proteins evolved enhanced catalytic capabilities through oxidative modifications.
• DNA adaptations under oxidative stress facilitated replication and transcription innovations.

3. Resonance and Molecular Coherence

Life’s processes rely on long-range molecular interactions mediated by electronic properties. Oxidation amplifies these interactions, forming coherent networks among proteins and nucleic acids. This electronic coherence is critical for complex cellular functions.

4. Oxidation and Aging

Interestingly, the same oxidative mechanisms that drive innovation also contribute to aging, reflecting evolution's trade-offs. Traits enhancing reproduction often come at the cost of long-term stability, highlighting the evolutionary balance between growth and preservation.

5. Towards an Interdisciplinary Approach

The insights from electronic biology challenge traditional views, merging physics, chemistry, and biology to reveal how molecular systems evolved under selective pressures shaped by electron behavior. By understanding how electrons sculpt life’s architecture, we unlock the potential for breakthroughs in medicine, aging, and disease prevention.

Conclusion: Evolution at the Subatomic Scale

Szent-Gy?rgyi’s vision positions electrons as the architects of life’s complexity. Oxidation, far from being merely a source of damage, emerges as a creative force in evolution, modulating the electronic properties of biomolecules and driving innovation. Embracing this electronic biology perspective doesn’t just deepen our understanding of evolution—it opens new frontiers in science and technology.

Let’s continue exploring how electrons, the smallest energy transfer units, hold the key to life’s greatest mysteries.