Researchers discover new molecules with longevity boosting potential

Spin out company Vitalunga to develop mitophagy-activating compounds that rejuvenate cells, and extend lifespan and healthspan in worm models.

Researchers at the Hebrew University of Jerusalem have discovered a new family of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function. The efficacy of the molecules was demonstrated on a model organism – the?C. elegans?roundworm. The research team examined the effect of various therapies on longevity and quality of life, and successfully showed they can protect the worm and human cells from damage.

The researchers, led by Professors Einav Gross and Shmuel Ben-Sasson, have founded a company called Vitalunga to advance the research and translate it into therapeutics.?

My take on this: A major factor in aging tissues is the reduced effectiveness of our cell’s quality-control mechanism, which leads to the accumulation of defective?mitochondria?– the cellular ‘power plants’ responsible for energy production. Mitochondria can be compared to tiny electric batteries that help cells function properly. Although these ‘batteries’ wear out constantly, our cells have a sophisticated mechanism called mitophagy that removes defective mitochondria and replaces them with new ones. However, this mechanism declines with age, leading to cell dysfunction and deterioration in tissue activity, and is implicated in many age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, heart failure and sarcopenia.

We spoke to Prof Ben-Sasson to find out more about the longevity potential of the new discovery and the next steps for the new company.

The fundamental science behind the new discovery is the idea that augmenting mitophagy may prevent the evolution of many age-related diseases.

“We realised for the first time there is a druggable target to treat multiple major diseases associated with aging,” says Ben-Sasson.

Read the full article HERE.

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