RESEARCH NEWS: IgG linked to metabolic decline, senolytic CAR T cells refresh metabolic function, red ginseng & healthy ageing, KIRRA for memory loss

One of the things we find makes a material difference in the current quality of life for our patients, is finding foods they are reactive to.?

Of the four immunoglobulins involved in direct immunological responses to food, IgG accounts for ~85%, and is pretty easily tested.?

Note there are some not-so-great tests out there for this too, unfortunately. Buyer beware.

We know identifying and removing the worst of the IgG provoking foods can move the needle in a big way, but now we have evidence that those same IgGs also accelerate ageing, which makes total sense. More IgG antibody-antigen complexes floating around means more inflammation (this study found fibrosis), which poses a challenge and distraction to the body in regulating towards optimal.

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Figure out how your body is responding to the world (food and otherwise), by listening to it, and testing.

Jabe Brown , Founder (Melbourne Functional Medicine)

Senescent cells: Targeting with CAR T therapy

Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan.

Red ginseng supports liver health and healthy ageing

Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related conditions.

Fighting memory loss with KIBRA

KIBRA improves brain connectivity and memory, providing defence against memory decline linked to tauopathy, prevalent in neurodegenerative conditions.

IgG linked to ageing and metabolic decline

Immunoglobulin G (IgG) accelerates ageing by causing fibrosis in fat tissue, which leads to a decline in metabolic health, highlighting potential targets for anti-ageing treatments.

To read these articles in full, visit our research feed.

#longevity #ageing #lifespan #healthspan #alzheimers #brainhealth #guthealth #neurodegeneration #cellularsenescence #heartanddiabetes #metabolichealth #senolytictherapy #supplements #cellularhealth #memory #cognitiveperformance