Regioselective One-pot transformation of 2’-hydroxy chalcones to 3,5-diphenylisoxazole via dehydrogenation of dihydroisoxazolines using Copper salt...

Milind V Gaikwad Download Pdf of the article

Volume 1, Issue 2 , Spring 2021, Pages 59-65 https://dx.doi.org/10.22034/jaoc.2021.278705.1010

Abstract  

A synthesis of series of 3, 5-diaryl isoxazoles has been described. The Cu salt in DMF with EDU base induces oxidative dehydrogenation of 2-(5-phenyl-4,5-dihydroisoxazol-3-yl) phenol results in the formation of 2-(5-phenylisoxazol-3-yl) phenol in excellent yields under mild reaction conditions. The present protocol contains cheap catalyst, easy workup, normal reaction conditions and high selectivity.

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