Reasons for a New Microbiome-Based Company

In the fifteen, perhaps a little longer, the importance of the brain-gut axis, the complex interactions of the intestinal microbiota with the immune system, advances in the genomics of microorganisms, and the discovery that ulcerative colitis resulting from clostridium difficile can be controlled or cured by fecal transplantation (or fecal implanting) was followed by evidence of a favorable response to this treatment in IBS (inflammatory bowel disease), irritable bowel syndrome; and then in obesity, insulin resistance and diabetes mellitus. Later, it was effective in multiple sclerosis, Parkinson's disease, and other clinical conditions.

This set of information, combined with the scientific community's thirst for breaking paradigms, led to the belief that the human gut microbiome is much more beneficial than previously imagined. Consequently, its pathogenic stigma was gradually dismantled, and its potential was transformed into a hype that does not find much additional medical or scientific support.

Not limited to isolated healthy individuals, the human gut microbiome in all populations serves as the habitat for numerous pathogens that adapt and thrive within it. Diseases of the oral-fecal cycle arise from the exposure of human populations to untreated water, contaminated with human waste and excessive fecal coliforms (FC).

Incidentally, FC is a key indicator in the science of sanitation, serving as a tool to define water (and environment) quality, both potable and for bathing, including saline water.

Above a certain threshold, high levels of coliforms indicate well-established risks for diseases such as salmonellosis, gastroenteritis, colitis, hepatitis, amoebiasis, helminth infections, protozoan diseases, viral infections, and cholera, among others.

However, ambivalent thinking about the gut microbiome is growing overwhelmingly, especially in countries or regions where efficient and expensive sewage networks are in place, where waste is correctly processed, where there is universal access to clean water, and where there are disposables, and plenty of sinks, soaps, and paper towels. These regions also have less contaminated rivers, have defeated cholera, experience rare gastroenteritis, and have practically eliminated salmonellosis.

Another misconception, but deeply disseminated, is the overvaluation of the intestinal microbiota, arguably the most abundant in us, to the detriment of the correct understanding that our microbiome is infinitely more complex, qualitatively involving a much greater set of microorganisms inhabiting our skin, hair, nails, and orifices.

Also overlooked is the understanding that individuals' microbiomes interact for good, and sometimes, for evil, as in infectious diseases. Serological, parasitological, and microbiological screening of stool donors is much more complex than that used for blood donors.

Furthermore, we often forget that we need to continually replenish our microbiome and that nature did not make us self-sufficient in microorganisms, which it was supposed to supply eternally.

In my personal view, and based on extensive research, as a doctor who lives and works in one of the most unequal continental countries in the world—where a smaller portion of the population with access to high hygienic and cultural standards coexists with a vast human contingent without access to sewage and treated water, and where these two realities collide —i t became clear that the suppression of access to the pathogenic intestinal microbiome through the achievements of civilization (sewage, education, hygiene, and clean water) also results in the blockage of access to the beneficial microbiome of nature. Unfortunately, this also generates disease.

Upon understanding these truths, I studied especially ME/CFS and fibromyalgia, a complex of diseases whose expansion is much more expressive in developed countries, but also on the most privileged humans of developing nations, and I understood that returning to nature and its vast and balanced microbiome would be the process to restore the integrity of life.

The practice of medicine in smaller cities and communication with medical colleagues dispersed in the vastness of a country still rich in forests and natural biomes led to the realization that this disease does not exist in the rural environment in Brazil.

Under this view, it would not be the transplanted gut microbiome that would improve this condition. In this sense, a fecal transplant experiment in Denmark failed miserably to show clinical improvements, for me no surprise. Not necessarily, the microbiota of a healthy person will make a sick person healthy.

Instead, I got convinced that only a representative, naturally balanced, and potent blend from the microbiome of forests, woods, clean rivers, lakes, uncrowded beaches, and other natural environments, would be the medicine to heal and restore the quality of life of the civilized homo sapiens.

With this in mind, extensive work resulted in rich, non-pathogenic microbial blends obtained from untouched regions of the Atlantic Rain Forest. At the same time, I was developing a unique, reproductive, and fast expansion/production method.

For one year, I, my offspring, colleagues, and many friends consumed the natural Blend #352 afterward administered to 260 ME/CFS and fibromyalgia patients in a long research. This work is published under the title Pandemics Entangled?, the first editorial project on LinkedIn, soon to be printed.

In the last three millennia, mankind ingeniously discovered how to cultivate fermenters, and thus kombucha and kimchi appeared in Asia; plus kefirs and yogurts in the Middle East. Fermented food includes cheeses, beers, wines and liquors, and breads and cakes common in the West; pulque in Mexico; and chocolate in Central America. There are numerous other examples around the world. In Brazil, since pre-Columbian times millenary techniques for fermentation of nutritious roots are still widely practiced. But none of these foods are as complete, potent, or sufficient for maintaining or restoring health (or the environment) as living in nature.

But now, thanks to entrepreneurship, the fusion of ancient knowledge with zymological, microbiological, metagenomics, and medical microbiology made it possible to bring a self-balanced and more powerful set of elements from different natural microbiomes into civilization. This advancement has various applications in human health, agriculture, livestock, veterinary medicine, the recovery of degraded forests, contaminated waters and areas, and environmental bioremediation.

Microbio.World is born TODAY!