Today's Newsletter is about Rapamycin, while I am not going to give a detailed lecture preaching to the crowd on it I want to provide a few details.
Rapamycin has been on the radar for over a decade now as an anti-aging intervention, and for good reason, it works!
It consistently extends lifespan across organisms and reduces mortality/morbidity, as far as replication of studies and gold standards exist it is as good as it gets.
A few facts about Rapamycin and aging:
- It extends average lifespan with about 15% in mice and also maximum lifespan
- It also works synergistically with Metformin who by itself is a weaker anti-aging drug, current data when paired gives a life extension with over 20%, this could speculatively be due to Metformin's blood lipid lowering and sugar lowering effects (that are elevated with Rapamycin treatment)
- Rapamycin is antifibrotic (fibrosis is one major cause of heart problems with aging together)
- Rapamycin reduces the hyperactivation of mTOR that occurs with increasing age (it's target), the lowering of excessive growth factors reduces cancer risk.
- Rapamycin is about as effective when initiating treatment in middle age as in youth (so in theory you could wait with starting it until you are 40-50 years old and still get as much benefit from it as someone starting at age 20). If anyone wants independent guidance on what the science says, book at meeting at: Calendly - victor bjork
Life Science and Biosimulations Expert | Research Director | Translational Science | PK-PD | AI | Leadership | Strategic Planning | Project Management | Business Acumen | Oral and Written Communications|
5 个月This is quite intriguing. Has anybody examined the telomere length in mice treated with rapamycin? Also, are there any human studies? Thank you
Vitalist | Founder Rapamycin Longevity Lab (MasterOneThing.com)
1 年?? what is your view on the combination of acarbose and rapamycin compared to metformin and rapamycin?
Professor at University of Maryland
1 年Yes, I know several people who use it. However, I have IBD and rapamycin prevents regrowth of the intestinal lining (as might be expected as it shifts mTOR to growth rather than repair. I'm more interested in reversing aging than slowing it, but I have to live long enough to accomplish that and 15% ain't nothing. I wonder if it also works with CR, or would it be redundant?
生命科学/生物技术博士 Life Sciences/Biotech PhD
1 年From my previous previous job in Germany, there is a group to learn aging with rapamycin and metformine in fly. It was a big news in the field. If you are interested in, please have a look at MPI ageing homepage and the director research who is from UK and should already gone back to UK after she retired from MPI