Quick guide on Xyloflo ( Nasal Drops for Mucosal Decongestion

Key Ingredients:

• Xylometazoline Hydrochloride IP 0.1% w/v

• Benzalkonium Chioride Solution IP 0.02 %v/y

• Aqueous isotonic solution qs.

Xyloflo Nasal Drops is a nasal decongestant medicine that works by shrinking the blood vessels present in the nose and relieves stuffy noses caused due to allergies, sinus infections, and common colds.

Key Benefits:

• The nasal drops cause the blood vessels in the lining of the nasal passages and sinuses to contract and narrow

• It aids in decreasing blood flow into the nose and sinuses

• It reduces swelling and feelings of congestion

• It assists in reducing mucus production and relieves a blocked nose

Concerns It Can Help With:

• Nasal congestion

• Stuffy nose

Product Form: SpraySuitable For: AdultsDosage:

• Adults and children over 6 years: 2-3 drops into each nostril per application

• A total of 3-4 applications per day is usually sufficient or as directed by the healthcare professional

Directions for Use:

• Clean the nose by blowing gently

• Lie with the head lower than the shoulders

• Press the bottle gently and lower the nozzle a little way into each nostril and apply 2-3 drops

• Remain still for a few minutes

Safety Information:

• Read the label carefully before use

• Store in a cool and dry place

• Do not allow to freeze

• Keep out of reach of children

XYLOFLO NASAL DROPS contains Xylometazoline which belongs to the group of medicines called Nasal decongestants. It is used in adults and in adolescents (aged 12 years or above) to provide relief from nasal congestion caused due to common cold, sinusitis (inflammation of the sinuses) or allergic rhinitis (an allergic condition)

Always use XYLOFLO NASAL DROPS as directed by your physician. It is for intranasal use only. Do not use XYLOFLO NASAL DROPS for more than 7 days without consulting your doctor.

Before using XYLOFLO NASAL DROPS inform your doctor if you have diabetes, hypertension, glaucoma, hyperthyroidism, or any heart problems. You must also inform your doctor if you have any other problems in nasal tract apart from nasal congestion such as chronic nasal inflammation with very dry nasal passages (rhinitis sicca or atrophic rhinitis).

Consult your doctor before using XYLOFLO NASAL DROPS if you are pregnant, think you may be pregnant or breastfeeding. The most common side effects of using XYLOFLO NASAL DROPS are irritation or burning sensation after application and nasal dryness. Consult your doctor if any of these side effect worsens.

USES OF XYLOFLO NASAL DROPS

It is used in adults and in adolescents (aged 12 years or above) to provide relief from:

• Nasal congestion (blocked nose)

HOW XYLOFLO NASAL DROPS WORKS

XYLOFLO NASAL DROPS opens and clears the nasal passages. It works by narrowing down the blood vessels supplying the nasal passage. This helps swollen blood vessels of the nasal tract to return to its normal size which allows the air to pass through the nostrils more freely. It also reduces excessive nasal secretions and provides temporary relief from nasal inflammation, swelling and discomfort.

DIRECTIONS FOR USE

Always use XYLOFLO NASAL DROPS as directed by your physician. It is for intranasal use only.

For Nasal Drops: Gently instill few drops of this medicine into each nostril. Clean the dropper after application.

For Nasal Spray: Insert the spray nozzle inside the affected nostril. Press the pump to release the spray and sniff at the same time. Repeat the same to the other nostril if required. Clean the nozzle after application.

To avoid possible spread of infection, this pack should only be used by a single person. Do not use XYLOFLO NASAL DROPS for more than 7 days without consulting your doctor. Discard the unused portion after 28 days of opening it.

SIDE EFFECTS OF XYLOFLO NASAL DROPS

COMMON

• Dry nose
• Nose discomfort
• Headache
• Nausea
• Irritation or burning sensation after application

UNCOMMON

• Nosebleeds

RARE

Stop using XYLOFLO NASAL DROPS and contact your doctor immediately if you experience any of the following side effects:

• Severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
• Severe itching of the skin, with a red rash or raised spots on the skin.

HOW TO MANAGE SIDE EFFECTS

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Take XYLOFLO NASAL DROPS with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

Consult your doctor before using XYLOFLO NASAL DROPS if you are pregnant or think you may be pregnant.

BREASTFEEDING

Consult your doctor

Consult your doctor before using XYLOFLO NASAL DROPS if you are breastfeeding.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any tools or machines if your ability is affected by XYLOFLO NASAL DROPS.

ALLERGY

Contraindicated

Do not use XYLOFLO NASAL DROPS if you are allergic to Xylometazoline or to any other ingredients of this medicine.

HEART DISEASE

Use with Caution

XYLOFLO NASAL DROPS should be used with caution in patients with heart disease (such as hypertension, prolonged QT syndrome). Therefore, consult your doctor before using it.

OTHERS

XYLOFLO NASAL DROPS is not recommended for use if you:

• Have had a recent neurosurgery
• Have narrow-angle glaucoma (increased pressure within the eyes)
• Have any problems in the nasal tract such as chronic nasal inflammation with very dry nasal passages (rhinitis sicca or atrophic rhinitis)
• Have an enlarged prostate gland
• Have phaeochromocytoma (a rare tumour of the adrenal glands)

Before using XYLOFLO NASAL DROPS, inform your doctor if you:

• Have diabetes
• Have hyperthyroidism (overactive thyroid gland)

Use in pediatrics:

XYLOFLO NASAL DROPS can be used in children and adolescents aged 12 years or above. You must consult your doctor before using XYLOFLO NASAL DROPS if your child is aged 6 years or above. It is not recommended for use in children aged below 6 years. Therefore, consult your doctor for advice before administration.

Use in geriatrics:

XYLOFLO NASAL DROPS should be used with caution in elderly patients. Therefore, consult your doctor for advice.

INTERACTIONS

A. Drug-Drug interactions:

Before using XYLOFLO NASAL DROPS, inform your doctor if you are taking any of the following medicines:

• Antidepressants (used to treat depression) such as monoamine oxidase inhibitors (Ex. moclobemide, isocarboxazid, phenelzine and tranylcypromine), tricyclic antidepressants (Ex. amitriptyline, nortriptyline), lithium, fluoxetine, sertraline, citalopram, escitalopram etc
• Medicines used to control blood pressure such as alpha-blockers (Ex. prazosin, terazocin) or beta blockers (Ex. propranolol, atenolol)
• Timolol, betaxolol (used to treat glaucoma in the eye)

Overdosage:

If you or anyone else accidentally applied too much of XYLOFLO NASAL DROPS, consult your doctor immediately.

SYNOPSIS

Drug:??Xylometazoline

Pharmacological Category:??Alpha-Adrenergic Agonist

Therapeutic Indication:??Nasal congestion, sinusitis, perennial allergic rhinitis

Dosage Forms:??Nasal Drops, Nasal Spray

MORE INFORMATION

• Keep XYLOFLO NASAL DROPS out of reach to children
• Store XYLOFLO NASAL DROPS at room temperature

FAQs

What is the use of XYLOFLO NASAL DROPS?

XYLOFLO NASAL DROPS is used to provide relief from nasal congestion caused due to common cold, sinusitis or allergic rhinitis.

Can XYLOFLO NASAL DROPS be used every day?

Use XYLOFLO NASAL DROPS for the duration prescribed by your doctor. Do not use XYLOFLO NASAL DROPS for more than 7 days without consulting your doctor. Prolonged use of XYLOFLO NASAL DROPS may worsen your condition.

Is it safe to use XYLOFLO NASAL DROPS?

Yes. XYLOFLO NASAL DROPS is one of the safe and well-tolerated medicine. It does not cause any harmful side effects. It may cause local irritation or burning sensation after application which is quite normal and disappears after a few minutes.

What are the side effects of XYLOFLO NASAL DROPS?

The most common side effects of using XYLOFLO NASAL DROPS are irritation or burning sensation after application and nasal dryness. Consult your doctor if they bother you.

Can XYLOFLO NASAL DROPS be used in children?

XYLOFLO NASAL DROPS can be used in children and adolescents aged 12 years or above. You must consult your doctor before using XYLOFLO NASAL DROPS if your child is aged 6 years or above. It is not recommended for use in children aged below 6 years. Therefore, consult your doctor for advice before administration.

Is XYLOFLO NASAL DROPS an antihistamine?

XYLOFLO NASAL DROPS is a sympathomimetic agonist. It directly acts on the alpha-adrenergic receptors of the blood vessels supplying the nasal tract and narrows them down. This reduces swelling of the nasal tract and allows the air to pass through the nostrils more freely.

How long it takes for XYLOFLO NASAL DROPS to work?

XYLOFLO NASAL DROPS may show its therapeutic effect after 5 to 10 minutes of application. It works by narrowing of blood vessels in the affected lining of the nose and helps to provide relief from congestion.

Can XYLOFLO NASAL DROPS cause rebound congestion?

Yes, XYLOFLO NASAL DROPS may cause rebound congestion (worsening of congestion due to nasal decongestant sprays) if you use for more than the duration recommended by your doctor.

REFERENCES

1. K.D. Tripathi. Adrenergic System and Drugs. Essential of Medical Pharmacology. 7th Edition. Page – 136.

2. Xylometazoline. ScienceDirect.com. [Accessed on 30th August 2022]. https://www.sciencedirect.com/topics/medicine-and-dentistry/xylometazoline#:~:text=Clinical%20Pharmacology%3A,Therapeutic%20Effect%3A%20Decreased%20nasal%20congestion

3. Ronald Eccles, Kaj Martensson and Shirley C. Chen. Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold. Taylor Francis Online. January 2010. [Accessed on 30th August 2022]. https://www.tandfonline.com/doi/abs/10.1185/03007991003648015?journalCode=icmo20

4. GlaxoSmithKline Consumer Healthcare (UK). Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 30th August 2022]. https://www.medicines.org.uk/emc/files/pil.5984.pdf

5. GlaxoSmithKline Consumer Healthcare (UK). Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 30th August 2022]. https://www.medicines.org.uk/emc/files/pil.1412.pdf