Q3 2024 Newsletter - Metabolism of degraders, gut metabolites, qNMR and more

Q3 2024 Newsletter - Metabolism of degraders, gut metabolites, qNMR and more

Our latest technical newsletter focusses on the following topics:

  • Metabolism of targeted protein degraders drugs such as PROTACs.
  • Novel fecal metabolites of inavolisib (GDC-0077).
  • The role of NMR spectroscopy in drug metabolism studies. In the article we briefly discuss ADME applications of NMR, use of?19F-NMR and mass spec as an alternative to traditional ADME studies, cryoprobe technology, and quantitative NMR.
  • Links to recent blogs and Hypha's "paper picks" on topics of interest around biotransformation and drug metabolism.

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