Proteros Biostructures Newsletter: November 2024
Excellence is our main asset
Excellence in project execution is fundamental - we deliver what we promise. We reach the milestones, meet timelines and agreed budgets. Our expertise warrants the design of scientifically relevant experiments that ultimately reach the RIGHT outcomes.
Proteros supports structural biology efforts for immune checkpoint blockade program
Abstract: Human CD200R1 (hCD200R1), an immune inhibitory receptor expressed predominantly on T cells and myeloid cells, was identified as a promising immuno-oncology target by the 23andMe database. Blockade of CD200R1-dependent signaling enhances T cell-mediated antitumor activity in vitro and in vivo. 23ME-00610 is a potential first-in-class, humanized IgG1 investigational antibody that binds hCD200R1 with high affinity. We have previously shown that 23ME-00610 inhibits the hCD200R1 immune checkpoint function. Herein, we dissect the molecular mechanism of 23ME-00610 blockade of hCD200R1 by solving the crystal structure of 23ME-00610 Fab in complex with hCD200R1 and performing mutational studies, which show 23ME-00610 blocks the interaction between hCD200 and hCD200R1 through steric hindrance.
Accelerate your discovery programs with high throughput screening via SPR!
We provide a powerful screening solution featuring one of the world's largest SPR facilities, equipped with multiple Cytiva Biacore 8K and 8k+ instruments. Our tailored service includes:?
Our proprietary compound pooling and hit deconvolution strategy maximizes efficiency, allowing us to deliver actionable insights quickly to drive your early-stage programs forward. Let’s unlock new possibilities together!
Events
?? PSDI 2024
?? November 10th-12th, 2024
?? Paris, France
Our Cryo-EM experts Eva Cunha, PhD and Maren Thomsen will be representing us at PSDI this month, ready to help with your challenging structural biology projects. This not-to-be-missed event for the industrial community of structural biologists will this year be an opportunity to continue discussions on the various techniques of integrated structural biology??
If you’re attending and would like to discuss your project and how we can help with our state of the art equipment and expert scientists, please get in touch below! ??
こんにちは、日本
(Or rather, Hello Japan!)
?? Client visits
?? November 18-22, 2024
?? Japan
We will be visiting Japan from November 18th - 22nd.? Dr. Tanja Vukicevic , VP of Business Development and Dr. Stephan Krapp , Co-Head of Structural Biology will be in Tokyo and Osaka visiting new and established PROTEROS biostructures GmbH clients.
If you’re based in Japan and would like us to visit you, please get in touch???
Our Services
DISCOVERY SOLUTIONS
We serve as our client's innovative catalyst, leveraging our cutting-edge technology platform and expert knowledge to drive novel solutions in drug discovery.
领英推荐
X-RAY CRYSTALLOGRAPHY
Elucidation of even the most complex structures through the preparation of the RIGHT protein.
ASSAYS, BIOPHYSICS & SCREENING
Our diverse range of services includes both pre-established and tailor-made assay development solutions designed specifically for profiling and screening applications.
BIOLOGICS
Your "one-stop-shop" solution for complex biologics / antigen purification with biochemical, biophysical and structural characterization.
CRYO-EM
Cutting edge Cryo-EM technology platform to deliver the RIGHT challenging proteins and complexes.
PROTEIN SCIENCES
At the heart of everything we do is the RIGHT protein for the right experiment. We ensure all proteins have the necessary unique characteristics to ensure your programs success.
PROVEN TRACK RECORD AT PROTEROS
Proven track record with 200+ pharma and biotech partners in US, Europe and Japan. Serving most of the world's 20 largest pharma companies.
Providing discovery support to hundreds of big, small, and virtual biotechs.
6,000+ Structures elucidated
10,000+ Projects completed
300+ Peer-reviewed publications
Cutting Edge Facilities to Foster Excellence
Located in the thriving Martinsried / Munich - Biotech Cluster in Germany, our cutting-edge facility has been meticulously designed to cater to our specific service execution demands. Each specialized area, including Structural Biology, Cryo-EM, Protein Sciences, Biologics, Biophysics and Screening, has dedicated floors and lab rooms. We have created an environment where all these disciplines coexist under one roof, fostering the seamless collaboration and synergistic interaction necessary for the success of Discovery Solutions and multi-disciplinary projects.
Copyright ? 2024 Proteros Biostructures GmbH
Mailing address:
EUROPE
Tel: +49 (0)89/700761-0 Fax: +49 (0)89/700761-115 Email: [email protected]
Headquarters: Proteros biostructures GmbH Bunsenstr. 7a D - 82152 Martinsried Germany Get directions
NORTH AMERICA
Tel: +1-213-924-1483 Email: [email protected]
Headquarters: Proteros USA Inc. One Broadway, 14th Floor Cambridge, MA 02142 United States Get directions