Proteros Biostructures Newsletter: March 2024
Excellence is our main asset
Excellence in project execution is fundamental - we deliver what we promise, we reach the milestones, meet timelines and agreed budgets. Our expertise warrants the design of scientifically relevant experiments that ultimately reach the RIGHT outcomes.
NEW Structures added to the Proteros Gallery!
With our extensive study of crystal systems, Proteros has developed advanced methodologies, protocols, and SOPs for the Gallery Structures. This means that we can offer you fast and reliable turnaround times, providing an ideal foundation for obtaining high-resolution Protein-Ligand-Structures (PLS) with your specific ligands of interest. In a matter of days, we can generate these structures ensuring a seamless experience for our customers. Visit our gallery which highlights over 300+ highly characterized proteins available for use, and over 200+ solved structures.
New additions include:
CRAF Completex Solved with Merck Group KGaA
Unraveling the complexities of challenging targets through Proteros’ innovative Cryo-EM Platform is a game-changer in the dynamic world of drug discovery. Proteros collaborated with Merck KGaA to accurately express the CRAF protein complex, confirming its activity and sequence using cutting-edge MS techniques and RDA readouts. The intricate structure was then revealed by our expert in-house Cryo-EM team. Dive deeper into the details by exploring the JMB paper and reach out to discover how our team can assist with your own challenging targets!
Proteros Gallery Structures Highlight: GLP-1R
GLP-1R is a key target in addressing metabolic disorders amidst the rising challenges of Type 2 diabetes and obesity. Through Cryo-EM structural analysis, the intricacies of GLP-1R interaction with G protein partners (GLP-1RG) are unveiled, paving the way for tailored agonists that enhance patient adherence to treatment. Proteros now offers the activated GLP-1R-Gabc as a Cryo-EM Gallery Structure, empowering our clients' drug discovery endeavors. Inquire below or explore our Gallery for a glimpse at our array of "off-the-shelf" proteins and structures that can readily be delivered in a matter of days to weeks.
Upcoming Events
March 12, 2024, CDD Vault: Community Meetup, Berlin, Germany
Smart Labs - Empowering Data-Driven Discovery hosted by Collaborative Drug Discovery - CDD Vault .? We're thrilled to be part of CDD Vault's 2024 Life Sciences Community Meetup on March 12, 2024, in Berlin! Joanna Deek , our esteemed Director of Business Unit Proteins, Biologics and Biophysics, will participate in the upcoming event: Smart Labs - Empowering Data-Driven Discovery hosted by CDD Vault.
Joanna will be presenting on Strategy for Unified Discovery Data and Elevated Scientific Exchange from 13:30 - 14:00. If you plan on attending and would like to connect to learn how PROTEROS biostructures GmbH can help support your research, please reach out to Dr. Tanja Vukicevic or Joanna Deek !
March 18-20, 2024, BIO EUROPE SPRING, Barcelona, Spain
Join us at BIO-Europe Spring on March 18-20, 2024, in Barcelona, Spain! Our structural biology experts Dr. Stephan Krapp and VP of Business Development, Dr. Tanja Vukicevic , are thrilled to be part of this event. This gathering of industry leaders in pharmaceuticals and biotech will delve into the current and future trends in life sciences. If you're attending and wish to explore how Proteros can enhance your projects, reach out to Dr. Tanja Vukicevic to schedule a meeting. Let's accelerate science together!
Proteros Discovery Solutions:? A Protein-centric drug discovery engine
Discover the RIGHT protein paired with the RIGHT building blocks for all your drug discovery needs. With cutting-edge structural biology, tailor-made assay development, a wide range of screening library access options, and the full spectrum of biophysical mode-of-action methodologies, our protein-centric approach ensures that no cog is missing in your drug discovery process.
"With this novel library, we aim to enable the exploration of a highly diverse chemical space for our customers"
– Dr. Lars Neumann, Director Business Unit Discovery Solutions
Proteros biostructures and Orion Pharma initiate a long-term multi-target collaboration while adding a joint novel and unique HTS small-molecule screening library with full chemistry support of Enamine
Under the agreement, Orion co-funded and supported the design and generation of the library containing a highly diverse collection of chemotypes for target-agnostic high throughput screening (HTS). The small molecule collection, of roughly 200,000 compounds, is distinguished by its novel and unique design concept of optimized chemical diversity.
"This unique design allows us to offer our clients an excellent option for discovering Qualified Hits for High Hanging Fruit targets."
– Dr. Debora Konz Makino, VP Business Unit Discovery Solutions
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Our Services
DISCOVERY SOLUTIONS
We serve as our client's innovative catalyst, leveraging our cutting-edge technology platform and expert knowledge to drive novel solutions in drug discovery.
X-RAY CRYSTALLOGRAPHY
Elucidation of even the most complex structures through the preparation of the RIGHT protein.
ASSAYS, BIOPHYSICS & SCREENING
Our diverse range of services includes both pre-established and tailor-made assay development solutions designed specifically for profiling and screening applications.
BIOLOGICS
Your "one-stop-shop" solution for complex biologics / antigen purification with biochemical, biophysical and structural characterization.?
CRYO-EM
Cutting edge Cryo-EM technology platform to deliver the RIGHT challenging proteins and complexes.
PROTEIN SCIENCES
At the heart of everything we do is the RIGHT protein for the right experiment. We ensure all proteins have the necessary unique characteristics to ensure your programs success.
PROVEN TRACK RECORD AT PROTEROS
+6,000 Structures elucidated
+10,000 Projects completed
300 Peer-reviewed publications
Cutting Edge Facilities to Foster Excellence
Located in the thriving Martinsried / Munich - Biotech Cluster in Germany, our cutting-edge facility has been meticulously designed to cater to our specific service execution demands. Each specialized area, including Structural Biology, Cryo-EM, Protein Sciences, Biologics, Biophysics and Screening, has dedicated floors and lab rooms. We have created an environment where all these disciplines coexist under one roof, fostering the seamless collaboration and synergistic interaction necessary for the success of Discovery Solutions and multi-disciplinary projects.
Copyright ? 2024 Proteros Biostructures GmbH
Mailing address:
EUROPE
Tel: +49 (0)89/700761-0 Fax: +49 (0)89/700761-115 Email:?[email protected]
Headquarters: Proteros biostructures GmbH Bunsenstr. 7a D - 82152 Martinsried Germany Get directions
NORTH AMERICA
Tel: +1-213-924-1483 Email:?[email protected]
Headquarters: Proteros USA Inc. One Broadway, 14th Floor Cambridge, MA 02142 United States Get directions