Proteros Biostructures Newsletter: January 2025
Excellence is our main asset
Excellence in project execution is fundamental - we deliver what we promise. We reach the milestones, meet timelines and agreed budgets. Our expertise warrants the design of scientifically relevant experiments that ultimately reach the RIGHT outcomes.
PROTEROS and Arbutus Biopharma co-publish study on the identification of Macrocyclic novel noncovalent inhibitors of SARS-CoV-2 Mpro.?
The recent global COVID-19 pandemic has highlighted treatments for coronavirus infections. The main protease (Mpro) has been an important target for the development of SARS-CoV-2 direct-acting antivirals. Proteros supported Arbutus with the identification and verification of these novel inhibitors in this project by designing and accurately producing the necessary purified Mpro protein and associated off-target proteins for proteolytic inhibition assays as well as ultra-pure protein for x-ray crystallography experiments. Assay ready proteins were utilized to identify IC50 values of various Macrocycles, along with kinetic binding measurements performed via in-house SPR. Finally, Co-crystal structures were delivered to confirm the binding mode of top performing Macrocycles.
See the full article at the link below to learn more and inquire with us at PROTEROS to discuss your program needs.
New Gallery Structures, Proteins and Assays now available at PROTEROS!
New Gallery Structures for Crystallography Include:?
New Gallery Structures for Cryo-EM Include:?
See the full list of available "off-the-shelf" proteins, structures and assays that are available to help kick-start your drug discovery program.
Our Services
DISCOVERY SOLUTIONS
We serve as our client's innovative catalyst, leveraging our cutting-edge technology platform and expert knowledge to drive novel solutions in drug discovery.
X-RAY CRYSTALLOGRAPHY
Elucidation of even the most complex structures through the preparation of the RIGHT protein.
ASSAYS, BIOPHYSICS & SCREENING
Our diverse range of services includes both pre-established and tailor-made assay development solutions designed specifically for profiling and screening applications.
领英推荐
BIOLOGICS
Your "one-stop-shop" solution for complex biologics / antigen purification with biochemical, biophysical and structural characterization.
CRYO-EM
Cutting edge Cryo-EM technology platform to deliver the RIGHT challenging proteins and complexes.
PROTEIN SCIENCES
At the heart of everything we do is the RIGHT protein for the right experiment. We ensure all proteins have the necessary unique characteristics to ensure your programs success.
PROVEN TRACK RECORD AT PROTEROS
Proven track record with 200+ pharma and biotech partners in US, Europe and Japan. Serving most of the world's 20 largest pharma companies.
Providing discovery support to hundreds of big, small, and virtual biotechs.
6,000+ Structures elucidated
10,000+ Projects completed
300+ Peer-reviewed publications
Cutting Edge Facilities to Foster Excellence
Located in the thriving Martinsried / Munich - Biotech Cluster in Germany, our cutting-edge facility has been meticulously designed to cater to our specific service execution demands. Each specialized area, including Structural Biology, Cryo-EM, Protein Sciences, Biologics, Biophysics and Screening, has dedicated floors and lab rooms. We have created an environment where all these disciplines coexist under one roof, fostering the seamless collaboration and synergistic interaction necessary for the success of Discovery Solutions and multi-disciplinary projects.
Copyright ? 2025 Proteros Biostructures GmbH
Mailing address:
EUROPE
Tel: +49 (0)89/700761-0 Fax: +49 (0)89-700761-115 Email: [email protected]
Headquarters: Proteros biostructures GmbH Bunsenstrasse 7a, D-82152 Martinsried Germany Get directions
NORTH AMERICA
Tel: +1-213-924-1483 Email: [email protected]
Headquarters: Proteros USA Inc. One Broadway, 14th Floor, Cambridge, MA 02142 United States Get directions